NIAID reports potential West Nile treatment

first_img The researchers decided to develop their treatment, a monoclonal antibody, after they found that antibodies taken from the blood of people who had recovered from West Nile fever could cure mice infected with WNV, the NIAID said. But antibodies derived from human blood vary in their ability to fight disease, and they can be accompanied by other potentially dangerous infectious agents, despite efforts to purify them. See also: To solve these problems, the research team “made 46 monoclonal antibodies against West Nile virus and then eliminated the less effective ones through a tedious molecular-level screening process,” the NIAID said. Then they worked with MacroGenics, Inc., Rockville, Md., to create a human-like version of the most effective antibody. WNV causes no symptoms or only a mild flu-like illness in most people. But in about 1 in 150 people infected, the virus invades the central nervous system and can be fatal. The United States had 2,470 reported cases of West Nile disease in 2004, with 88 deaths, according to the Centers for Disease Control and Prevention. Apr 25, 2005 (CIDRAP News) – Researchers have developed an antibody that can cure mice of West Nile virus (WNV) infection, a disease for which no specific treatment now exists, the National Institute of Allergy and Infectious Diseases announced yesterday. Oliphant T, Engle M, Nybakken GE, et al. Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat Med 2005 Apr 24 (early online publication) [Full text] The research, funded in part by the NIAID, is described in a report published online yesterday by Nature Medicine. “MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody,” the statement said. “The monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection.” A team at Washington University in St. Louis “developed an infection-fighting antibody that mimics one produced by people whose immune systems successfully fend off the West Nile virus,” the NIAID said in a news release. “The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile disease.” “We could give this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them,” senior investigator Michael Diamond, MD, PhD, said in the news release. “It also completely protected the mice against death.” NIAID news releasehttp://www.niaid.nih.gov/news/newsreleases/2005/Pages/westniletherapy.aspxlast_img read more

The interest of British tour operators and airlines for Croatia is growing

first_imgDuring the second day of the World Travel Market (WTM) at the stand of the Croatian National Tourist Board, Minister of Tourism Gari Cappelli held meetings with tour operators and airlines Thomas Cook, TUI, Ryanair and Saga.After the meetings, Minister Cappelli stated that he expressed satisfaction that the partners plan to expand their business in Croatia and that Croatia remains one of their most important markets. “Today we received confirmation from the most important partners in the British market that our tourism policy is moving in the right direction and that the Croatian market represents an exceptional tourism potential in which they plan to expand their offer. The London WTM fair traditionally brings the first impulses on which we base our estimates of tourist traffic trends in the next year, and based on the knowledge we received today, I can say that next year we will continue positive trends from the British and I believe other markets. Regardless of the return of competition from the markets of Greece and Turkey, the announcements and expectations are at the level of last year with the planned growth of up to 7 percent. ” said Minister Gary Cappelli. The number of arrivals from the UK is directly correlated with the number of flights from the market and the length of the flight period. The vast majority of flights start at the end of April and the beginning of May and the flights last until the middle or end of October. The tendency is to extend the flight season every year, and the same is expected in 2019, which was confirmed at WTM meetings. During the meeting at the fair Niall O’Connor i Gary butler Ryanair confirmed that it will open eight new routes to Zadar Airport in the new season, from the Czech Republic, Poland, Italy and Germany, and two new connections to Rijeka Airport, London and Manchester. On behalf of the tour operator TUI David Burling, Helen Caron i Lucy Ling at the meeting with Minister Cappelli, they pointed out that they are doing excellent business with our country and noted that they plan to introduce a new tourist tour City break on the route Zagreb-Plitvice-Krka-Split. During the first ten months of this year, British tourist arrivals increased by 8 per cent to almost 850, while overnight stays rose by 8 per cent to almost 4,4 million. British tourists mostly traveled to the regions of Dalmatia – Dubrovnik (36%), then Dalmatia – Split (23%) and Istria (20%), and spent most nights in hotels.last_img read more

Chinese tourists will break the record in outbound travel during the Spring Festival this year

first_img“The fact that the Chinese are willing to spend more money and time on travel is proof of the rise in living standards and incomeSaid Peng Liang, an employee of Trip.com’s tourist data research center. “As more Chinese travel abroad on vacation, the world will also benefit from Chinese development”, He concludes. Better wages and a simpler way to start a business through startups drive the middle class in China, but also in many other parts of the world. After allocating money to basic living needs, middle-class families spend their hard-earned money on travel, a luxury in the past. Source / photo: Chinese Internet Information Center; Travel Daily Media; Pixabay Chinese tourists are the drivers of the travel industry. By 2030, two-thirds of the global middle class is projected to live in Asia. In the next 10 years, the number of middle-class people will increase fivefold, to 3,2 billion, and will be the largest group of consumers, reports Travel Daily Media. The Chinese made 2019 million outbound trips during the 6,3 Spring Festival holidays, up nearly 12,5 percent from the same period last year. Ninety percent of Trip.com users have chosen high-quality travel products and services. Tourists prefer private tourist groups with tour guides and flexible driving schedules. Chinese tourists will travel to several overseas destinations during their holidays during the Spring Festival (Chinese New Year) in 2020, according to a report published by China’s largest online travel agency Trip.com Group. Chinese Internet Information Center. Thanks to the warm climate, Australia and New Zealand were among the most popular destinations for Chinese tourists during that period. Trips to Italy, the UK, Spain, Russia, France and the United Arab Emirates are also bestsellers, the report said. “Chinese tourists have booked trips to 419 overseas cities, to over 100 countries and regions, during a seven-day vacation starting on January 24, 2020.”, It is stated in the report of Trip.com, and it is added that both figures are new records for the company.last_img read more

Pumas win built on emotion

first_img But the enduring images were of Argentina players crying before kick-off as the national anthem played and the sight of exciting backs crossing the Ireland line from free-flowing moves. “It’s part of our DNA, we play with our heart in our hand,” Hourcade said after Argentina reached a World Cup semi-final for only the second time in their history. “We feel it inside and the players show this on the pitch before the game. “It was the same after the game, it was very emotional. “My mum is ill so that made me emotional as well. “Also with the anthem the emotion that we feel then translates on the pitch as well, and that’s the most important thing.” Argentina’s only previous World Cup semi-final appearance came in France eight years ago, but that was based on forward power alone rather than an all-round game which the Pumas currently possess. But the Pumas have sharpened their attacking claws since the Rugby Championship was formed in 2012 and they joined southern hemisphere super-powers Australia, New Zealand and South Africa in a four-team competition. The exhilarating Pumas scored four tries to set up a semi-final showdown with Australia next weekend, their 43-20 victory their first over Ireland since the 2007 World Cup in France. Argentina’s only concern on a momentous day at the Millennium Stadium was a leg injury to their skipper Agustin Creevy, the hooker forced off in the closing stages with an injury which could threaten his participation in the Twickenham semi-final. That quartet will now make the semi-final line-up at this World Cup after Australia sneaked past Scotland in the final quarter-final, and Hourcade said the growth of Argentinian rugby in the last three years had been enormous. “Since 2012 we started changing, we started building,” Hourcade said. “It’s not something that has just started, it goes a long way back. “But since that moment it was even more important. “Playing the best on a yearly basis requires a level of perfection that makes you get used to it. “This kind of game becomes normal, plus we like it. “This is how we feel about it and the players like carrying it through.” Pumas back-rower Juan Martin Fernandez Lobbe said Argentina had achieved their pre-tournament objectives by guaranteeing themselves at least seven games, with a semi-final and either a final or a bronze medal match to come. “We had some objectives at the start of the tournament, the first was to qualify and the second was to play seven games,” Fernandez Lobbe said. “Now we want to play on Saturday the 31st (in the final). “It’s going to be very tough, but it’s really nice because there’s nothing bigger than a World Cup. “To deliver like that today is awesome. “We saw the Wallabies in the summer, they have a very good team and a very good breakdown. “They play with a lot of freedom but it is a semi-final and we need to give everything on the pitch.” Argentina coach Daniel Hourcade spoke of an emotion-filled Pumas dressing room after the South Americans ended Ireland’s World Cup dream in Cardiff. Press Associationlast_img read more

Samuels, Beaton to join Hurricanes

first_imgEXPERIENCED West Indies batsman Marlon Samuels will be joining the Leeward Islands Hurricanes for the West Indies Cricket Board (WICB) Super50 competition scheduled to start later this month.This was revealed by Chief Operations Officer (COO) of the Leeward Islands Cricket Board (LICB), Vernon Springer, who also named two other regional players set to join the sub-regional franchise ahead of a preparatory camp here at the Sir Vivian Richards Cricket Ground starting January 9.“We have 20 guys who will be here over the next couple of days or over the next two weeks and we are going to have some trial games. We promised you we are going to have the best franchise and whatever it takes, we are going to make sure it works,” he said.“The other big name for you is Ronsford Beaton – the Guyanese fast bowler – who is also going to be part of our 20-man squad, and from last year we would have had Daron Cruickshank who is also coming back into the One Day squad,” he added.Antiguan all-rounder Orlando Peters has also been included in the training squad. (First Published In The Antigua Observer)last_img read more

B’ville baseball honors ALS awareness, sweeps F-M

first_img Tags: BaldwinsvilleBaseball When it took a 5-4, eight-inning defeat at Liverpool on April 25, the Baldwinsville baseball team suffered its first blemish of 2019, but it didn’t take long to face another extra-inning test.In the first game of its subsequent series against Fayetteville-Manlius last Monday night, the Bees had to come back to take the Hornets to eight innings, but pulled out a 4-3 decision.Jake Marshall saw the 1-0 lead he inherited vanish when F-M scored three times in the bottom of the first inning, two of them on Sean Arthur’s single.Marshall lasted until the fourth, when Chris AuClair relieved him. By then, it was tied, 3-3, helped by Nate Ray’s two hits and two RBIs, and it would stay that way the rest of regulation as the Hornets had John Egnaczyk take over in relief after Tom Coleman started.Still even in the top of the eighth, B’ville got Mike Carni to third base, and then Carni raced home when Egnaczyk uncorked a wild pitch.Then AuClair earned the final three outs, having gone 4 1/3 innings with seven strikeouts. Marshall struck out five as he and AuClair combined to limit F-M to four hits.All of this set up last Wednesday night’s second game of the series on the turf at Onondaga Community College, part of the Strike Out Lou Gehrig’s Disease Classic.This held a particular meaning for B’ville’s school community since Ray Middle School teacher Mike Pauldine is battling Amyotrophic Lateral Sclerosis.In an emotional pregame ceremony, Pauldine, in a wheelchair, threw out the ceremonial first pitch, to the applause of both teams and a large group of Ray Middle teachers who were present at the game.Next to all that, the contest itself did not quite have the same meaning, but it was still Savacool’s turn in the rotation, and unlike with Liverpool, he had little trouble getting the win as the Bees beat the Hornets 12-2.Over the first four innings, B’ville accumulated a 12-0 advantage. Carni doubled twice, driving in two runs as Marshall, Ray and Pat May matched that two-RBI output. Pat Anson and Lucas Robinson also drove in runs.Savacool did not need that much run support, but the big lead allowed him to exit after just five innings, having only allowed one hit while striking out 10. Mike Carr worked two innings in relief.Rain that fell overnight and lingered into Thursday morning postponed the third B’ville-F-M game, and the Bees got ready for this week’s series with West Genesee, the first time these two had met since last May’s extra-inning Section III Class AA final.Share this:FacebookTwitterLinkedInRedditComment on this Story last_img read more

Penn State : Peaceful events at Paternoville provide stark contrast from Wednesday riots

first_img Facebook Twitter Google+ Published on November 10, 2011 at 12:00 pm Contact Jon: jdharr04@syr.edu UNIVERSITY PARK, Pa. — In Paternoville, the scene was much different Wednesday night than the one on College Avenue. There weren’t any riots, tipped over television news trucks or downed lampposts. Instead, there was silence.The students in Paternoville huddled around the Joe Paterno statue outside Beaver Stadium and took in the news. The legendary football coach — the man idolized in bronze right in front of them — had been fired in the midst of his 46th season at Penn State.The coach with the most wins in Division I college football history and Penn State President Graham Spanier were removed by the Board of Trustees on Wednesday night in light of a sexual abuse scandal involving former assistant coach Jerry Sandusky.‘Someone tried to start a ‘We Are’ chant and it was just not the right time because we just all wanted to reflect on what just happened,’ said Sam McLoota, a senior supply chain major. ‘That’s another tough thing, it’s hard to see this all go down when you go this school and you love it so much. We just got to fight through and go to this game on Saturday and see us pick up the W.’The 12th-ranked Nittany Lions (8-1) will face No. 19 Nebraska (7-2) at noon Saturday in Beaver Stadium. But those in Paternoville, the place where students camp out for first-row seats at an upcoming home game, are hoping to defeat more than the Cornhuskers this weekend. They’re hoping to overcome the negative attention given to Penn State since the riot Wednesday night.AdvertisementThis is placeholder text‘The whole week we’ve been hearing stuff, all the news outlets about how we look bad because we’re doing those things,’ said McLoota, adding that only a small portion of Penn State’s more than 38,000 students participated in the riot Wednesday night.McLoota, who is participating in Paternoville for the third time, said he wasn’t planning on camping out this week until he and Kevin Turk, a senior professional golf management major, saw on Twitter that some spots in the tent-filled village outside Beaver Stadium remained open. McLoota camped out for the Iowa game during his sophomore year and the Illinois game while he was a junior.McLoota and Turk bought a $90 red and white tent and made camp Wednesday afternoon, making sure to get a spot on the inside to guard against the wind. It was about 40 degrees out with a chilly breeze Thursday night.For McLoota, camping out for the Nebraska game was an opportunity to see Paterno coach for the last time — until Wednesday night’s news broke.‘I wasn’t planning on doing it for this, but when they said it was going to be Joe’s last game at home, I really wanted to be a part of it so I came out here,’ McLoota said. ‘Unfortunately that’s not the case, but we’re still out here for the team and that’s a good thing. We’re still all behind this team and we’re all going to be there cheering them on Saturday.’Turk, while playing trashcan football with McLoota and two other friends, said the news of the past week is hard to sum up. In trashcan football, there are two teams with two players each, two footballs and two trashcans side by side. Once a player makes it in the trash with the football, the other team flips the lid to show that can has been hit. The first team to make two cans wins.‘It’s just been a whirlwind. It’s hard to even tell what day it is with how much stuff has been going on,’ said Turk, as the football made a loud bang against the hard plastic of one of the blue trashcans. ‘It’s a shame in many situations that the act of a few can tarnish the reputations of many, whether it’s the actual situation at hand or the riots last night, which is obviously a small, small portion of the students.’Mark Mularczyk, a junior history major, and Matt Wargon, a junior engineering major, have been camping out in Paternoville since 8 p.m. Monday. Mularczyk has participated in Paternoville for every home game this year, while Wargon has been in Paternoville for every home game since freshman year.But Wargon has never experienced a week like this one.‘We’re trying to be out here holding down the fort, trying to show everybody that not all of Penn State is downtown rioting,’ he said. ‘Some of us are doing what Joe thinks is best, which is behaving like normal people and acting civilized and supporting the team and kids.’If the riots had to happen Wednesday night, Mularczyk said, he wishes students would have gathered for the children, who are the victims of this tragedy.‘We can still support JoePa by being rational people, not rioting downtown,’ Wargon said. ‘I wish it didn’t have to be this way but this is just the way things played out.’jdharr04@syr.educenter_img Commentslast_img read more

Trojans face another top-5 opponent

first_imgThe USC men’s volleyball team is riding high this season after defeating UC Irvine to improve to 3-0 on the season. The Trojans are currently ranked No. 5 in the nation, and are set to move up in the rankings after their grueling 5-set victory over the No. 8 Anteaters, who won the national championship  the last two years in a row.The Trojans will aim to remain undefeated tonight when they host the No. 3 Pepperdine Waves at the Galen Center. The Waves (2-0) are coming off two impressive wins against UC Irvine  and UC San Diego,  and are looking to avenge their loss to the Trojans from last season.Good service · Junior setter Micah Christenson has tallied 147 assists in the Trojans’ three wins over Loyola-Chicago, UC San Diego and UC Irvine. Joseph Chen | Daily TrojanIn last year’s match, the underdog Trojans, then ranked No. 15 nationally, upset the third-ranked Waves in four sets. Then-sophomore middle blocker Robert Feathers led the way with 13 blocks, while then-sophomore outside hitter Cristian Rivera added 11. Both are looking to repeat their success against the Waves tonight, entering the match averaging two kills per set each.Meanwhile, outside hitter Josh Taylor leads the Waves with 5.43 kills per set. Opposite/middle blocker Parker Kalmbach is the next-biggest contributor, with 4.29 kills per set.Last August, Taylor competed with Team USA in the men’s Pan American Cup in Mexico City, where the U.S. team fell in the first round. USC’s junior setter Micah Christenson has also played at the national level, representing Team USA in the 2013 NORCECA Men’s Continental Championship in Langley, B.C., Canada. Christenson contributed 18 sets and two blocks in the championship match, in which Team USA defeated Canada.With such competitive players on both teams, the match is sure to be enticing.“Pepperdine is very much on the rise,” Christenson said. “We’re excited to get going against someone other than each other.”Redshirt junior serving specialist Paul Yoder asserted that the team has prepared extensively to play against highly ranked teams such as the Anteaters and the Waves.“We’ve been coming together really well as a team this year and that’s been a big focus of ours,” Yoder said. “[It’s] really just getting into the gym everyday and it’s not always about being perfect but it’s about growing each and every step of the way.”The match will be held at the Galen Center at 7 p.m. It will be broadcast live on the Pac-12 Networks.last_img read more

Stave shut down indefinitely

first_imgUpdate: Badgers head coach Gary Andersen told reporters after this story was published that Stave is still out indefinitely, but not because of an injury. Read our update on that news conference and stay tuned for more developments of Stave’s condition and Wisconsin football coverage.Update: Stave out indefinitely but not injuredThe Wisconsin football quarterback situation took another confusing turn Monday afternoon following practice, with Joel Stave remaining out indefinitely, but Read…The Wisconsin football team’s quarterback situation just got that much more interesting with some oddly timed injury news.After stating in his press conference Monday afternoon that the top two quarterbacks, Tanner McEvoy and Joel Stave, would play, head coach Gary Andersen announced Tuesday that Stave has had lingering shoulder problems and will sit out for an undetermined amount of time.“Joel has been dealing with some issues with his throwing shoulder for the last couple of weeks and we have come to a decision, after talking with Joel, that the best thing for him right now is to shut it down and give him some rest,” Andersen said in an injury update Tuesday morning. “It was a tough decision because Joel is a great competitor and has a tremendous desire to help this team. We will continue to monitor his progress but we’re not putting a timetable on his return at this time.”Stave originally injured his throwing shoulder during UW’s New Year’s Day loss to South Carolina in the Capital One Bowl and still has yet to make a full recovery. With Andersen’s description of the injury, Stave’s health very well might have decided the quarterback job.The announcement comes as part two of a confusing sequence of events related to injuries. Following Saturday night’s 28-24 loss to LSU both Andersen and star running back Melvin Gordon confirmed that Gordon was healthy and the lack of second half carries was due to a coach’s decision. Then Monday afternoon in his press conference, Andersen said Gordon suffered a hip pointer and the staff was just trying to keep him fresh during the second half of play.As far as what Stave’s injury means for Wisconsin, Tanner McEvoy will still start Saturday’s game as planned. However, instead of the possibility of using Stave should McEvoy run into trouble, McEvoy will be the starter for the foreseeable future until Stave recuperates his shoulder. Bart Houston is currently the third string quarterback, but the redshirt sophomore has yet to see significant playing time in a game in his career.last_img read more

Women’s basketball: Badgers lose heartbreaker to Northwestern on Senior Day

first_imgIt was Senior Day at the Kohl Center for the Wisconsin women’s basketball team, and it wouldn’t have been more fitting for one of the three active members of the senior class to be the hero.AnnMarie Brown had that opportunity, but she couldn’t convert a layup in the waning seconds of overtime, as Wisconsin fell to Northwestern 86-83 Sunday afternoon.“It’s like any other shot, you have basically a 50-50 shot of making it,” Brown said. “And that one didn’t seem to go in. I can’t do anything about it. I tried. I did what I could.”The Badgers (8-18, 4-12 Big Ten) were down by eight with 59.7 seconds left during the overtime period, trailing 80-72. A layup from junior guard Dakota Whyte, followed by a three-pointer from Brown and another three from fellow senior Jacki Gulczysnki off a Wildcat turnover made it 82-80 with 26 seconds remaining.Northwestern’s Karly Rozer then sunk two foul shots to up the Wildcats’ lead to four, but Brown grabbed an offensive rebound and converted an and-one. Her free throw made it 84-83.Junior guard Tessa Cichy immediately fouled Northwestern’s Christen Inman on the inbound. Inman, who had missed from the free throw line only once in Big Ten play this season, missed her first one but made the second, making it 85-83.“It felt like we were in control in the overtime,” Northwestern head coach Joe McKeown said. “We were up seven, eight, nine, but they kept coming back and made plays. So you gotta give them a lot of credit.”That set up the Badgers with an opportunity to win the game, and when junior guard Nicole Bauman drove down the lane and dished it to Brown all alone on the left block, the game was surely to be tied once again.It did not work out that way.Wisconsin had yet another chance after Northwestern (21-6, 11-5 Big Ten) went 1-2 from the line, this time with 2.8 seconds to go. Brown had the chance to be the hero once more with the possibility of a half-court heave to send the game to a second overtime, but couldn’t get the shot off before time expired.“To the kids’ credit, they kept playing,” Wisconsin head coach Bobbie Kelsey said. “No one could say that the Badgers give up, or hang their heads.“And I feel so bad for AnnMarie. She’s been through so much, and to miss that shot, which she makes all the time, she doesn’t miss a lot of layups around the basket. Maybe she was just so wide open she couldn’t believe it.”Northwestern tied the game with 1.4 seconds left in regulation off an inbound, when Maggie Lyon drained a 12-foot baseline jumper, the first time the teams had been tied since 17-17. The possession before that Whyte made one of her two free throws, which gave Northwestern the chance it needed to tie the game without having to shoot a three. The Wildcats had originally missed two other attempts before a scramble for the ball resulted in a jump ball with the possession arrow in favor of the Wildcats.“We’ve got some tough kids, like a Maggie Lyon or a [sophomore] Nia Coffey, who can just make a play,” McKeown said.Coffey led the Wildcats in scoring with 21 points, while Lyon added 15. Three more Wildcats scored in double figures: Lauren Douglas and Ashley Deary had 12 apiece, while Inman scored 11.Bauman led the Badgers scoring attack, pouring in 22, while Gulczynski had 19, going 5-10 from three. Senior Cassie Rochel had her fifth double-double of the season, scoring 12 points and grabbing 13 rebounds.The Badgers led by as many as 15 in the second half, when Whyte hit a three from the far baseline. After Bauman hit a three with 5:32 remaining in regulation, the Wildcats keyed up a 8-0 run in the next two minutes and 30 seconds to cut the Wisconsin lead to 65-63.“We just started kinda playing not to lose,” Brown said. “Rather than just keep shoving the ball down their throats and going for the win … We’ll bounce back. We know we’re there.”Both teams struggled offensively in the first half, particularly Northwestern, a result of sloppy play and poor shooting.The Wildcats last field goal of the half came with 8:29 to go and their only points came from two free throws the rest of the half. They shot 35.7 percent from the field, while Wisconsin shot 41.2 percent.Wisconsin had nine turnovers in the half, finishing with 23 total, allowing Northwestern to score 25 points off turnovers in their seventh straight victory.“It’s easy to get down when you’re losing, and say, ‘Let’s just pack it in,’” Kelsey said. “But we owe it to our seniors to play hard, and to ourselves, to keep fighting. Because you can build on fighting, but you can’t build on quitting. And they didn’t quit.”last_img read more