NIAID reports potential West Nile treatment

first_img The researchers decided to develop their treatment, a monoclonal antibody, after they found that antibodies taken from the blood of people who had recovered from West Nile fever could cure mice infected with WNV, the NIAID said. But antibodies derived from human blood vary in their ability to fight disease, and they can be accompanied by other potentially dangerous infectious agents, despite efforts to purify them. See also: To solve these problems, the research team “made 46 monoclonal antibodies against West Nile virus and then eliminated the less effective ones through a tedious molecular-level screening process,” the NIAID said. Then they worked with MacroGenics, Inc., Rockville, Md., to create a human-like version of the most effective antibody. WNV causes no symptoms or only a mild flu-like illness in most people. But in about 1 in 150 people infected, the virus invades the central nervous system and can be fatal. The United States had 2,470 reported cases of West Nile disease in 2004, with 88 deaths, according to the Centers for Disease Control and Prevention. Apr 25, 2005 (CIDRAP News) – Researchers have developed an antibody that can cure mice of West Nile virus (WNV) infection, a disease for which no specific treatment now exists, the National Institute of Allergy and Infectious Diseases announced yesterday. Oliphant T, Engle M, Nybakken GE, et al. Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat Med 2005 Apr 24 (early online publication) [Full text] The research, funded in part by the NIAID, is described in a report published online yesterday by Nature Medicine. “MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody,” the statement said. “The monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection.” A team at Washington University in St. Louis “developed an infection-fighting antibody that mimics one produced by people whose immune systems successfully fend off the West Nile virus,” the NIAID said in a news release. “The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile disease.” “We could give this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them,” senior investigator Michael Diamond, MD, PhD, said in the news release. “It also completely protected the mice against death.” NIAID news releasehttp://www.niaid.nih.gov/news/newsreleases/2005/Pages/westniletherapy.aspxlast_img read more

SIMEC Atlantis Divests Its Canadian Tidal JV

first_imgSIMEC Atlantis said it has completed the proposed sale of the company’s stake in its Canadian joint venture at the FORCE facility in Nova Scotia, Canada, to its renewable energy development partner DP Energy group.DP Energy has acquired the remaining 50% interest in Atlantis Operations (Canada) Limited (“AOCL”). Following completion, AOCL will be renamed to become Rio Fundo Operations Canada.The cash transaction enables the DP Energy group to take a more integrated approach to the AOCL berth alongside its pre-existing wholly owned berth at the FORCE facility. This transaction returns C$400,000 to SIMEC Atlantis and, according to the company, allows the management team to focus resources on other opportunities in the UK, France and Asia and will allow the DP Energy team to focus efforts on the development of the tidal stream industry in Nova Scotia.Tim Cornelius, Atlantis CEO, said: “I am pleased that we have been able to agree this sale with DP Energy. They have experience and presence in Canada and are well suited to deliver a project in Nova Scotia. This transaction returns value to our shareholders and allows us to focus on the exciting opportunities across the SIMEC group.”Simon De Pietro, DP Energy director, said: “DP Energy is delighted work with the Nova Scotia Government to promote the development of tidal energy as a major source of renewable electricity production in Canada and we are eager to take on the exciting challenges provided by the tidal resource in the Bay of Fundy. The venture adds further depth to the growing portfolio of renewable energy projects of the DP Energy group of companies worldwide. “last_img read more

B’ville baseball honors ALS awareness, sweeps F-M

first_img Tags: BaldwinsvilleBaseball When it took a 5-4, eight-inning defeat at Liverpool on April 25, the Baldwinsville baseball team suffered its first blemish of 2019, but it didn’t take long to face another extra-inning test.In the first game of its subsequent series against Fayetteville-Manlius last Monday night, the Bees had to come back to take the Hornets to eight innings, but pulled out a 4-3 decision.Jake Marshall saw the 1-0 lead he inherited vanish when F-M scored three times in the bottom of the first inning, two of them on Sean Arthur’s single.Marshall lasted until the fourth, when Chris AuClair relieved him. By then, it was tied, 3-3, helped by Nate Ray’s two hits and two RBIs, and it would stay that way the rest of regulation as the Hornets had John Egnaczyk take over in relief after Tom Coleman started.Still even in the top of the eighth, B’ville got Mike Carni to third base, and then Carni raced home when Egnaczyk uncorked a wild pitch.Then AuClair earned the final three outs, having gone 4 1/3 innings with seven strikeouts. Marshall struck out five as he and AuClair combined to limit F-M to four hits.All of this set up last Wednesday night’s second game of the series on the turf at Onondaga Community College, part of the Strike Out Lou Gehrig’s Disease Classic.This held a particular meaning for B’ville’s school community since Ray Middle School teacher Mike Pauldine is battling Amyotrophic Lateral Sclerosis.In an emotional pregame ceremony, Pauldine, in a wheelchair, threw out the ceremonial first pitch, to the applause of both teams and a large group of Ray Middle teachers who were present at the game.Next to all that, the contest itself did not quite have the same meaning, but it was still Savacool’s turn in the rotation, and unlike with Liverpool, he had little trouble getting the win as the Bees beat the Hornets 12-2.Over the first four innings, B’ville accumulated a 12-0 advantage. Carni doubled twice, driving in two runs as Marshall, Ray and Pat May matched that two-RBI output. Pat Anson and Lucas Robinson also drove in runs.Savacool did not need that much run support, but the big lead allowed him to exit after just five innings, having only allowed one hit while striking out 10. Mike Carr worked two innings in relief.Rain that fell overnight and lingered into Thursday morning postponed the third B’ville-F-M game, and the Bees got ready for this week’s series with West Genesee, the first time these two had met since last May’s extra-inning Section III Class AA final.Share this:FacebookTwitterLinkedInRedditComment on this Story last_img read more

Spirit of Halloween

first_imgErica Christianson (left), a junior majoring in political science, and Ella Yan, a sophomore majoring in international relations, play with trick-or-treaters from the community at URSC’s Spirits at Troy Carnival on Wednesday in McCarthy Quad. The event also featured face painting and Halloween-themed games.Joseph Chen | Daily Trojanlast_img

Research update: Domestic Perceptions Research 2016

first_imgSouth Africa is a diverse country, yet most of its people see themselves as South African first, according to Brand South Africa’s latest Domestic Perceptions Research. They also view themselves in a positive light and believe that media is a little too critical about the nation.During the past week Brand South Africa received results from the Domestic Perceptions Research study. This concludes two rounds of fieldwork conducted in the 2015/16 financial year. The research results of the two rounds, consolidated in one report, renders some interesting information about the perceptions South Africans have of the brand, and their outlook for the future.This research update merely reflects on a few issues pertaining to self-description, pride, media consumption and perceptions of how the media reports on issues in the domestic environment. More updates on findings from the domestic research to follow.Self-description labelsBeing a South African is a very important element of individual and national identity.In terms of nationality responses to the survey indicate – “I’m a South African” is the primary descriptive label amongst citizens.Unlike perceptions created through mediated debate, South Africans are extremely proud of the country:Over 80% of South African citizens claim that they are extremely proud to be South African. Citizens are inclined to recommend South Africa across the board, with higher affinity to travel to and live in. The box below indicates, by race, the predominant categories of self-description respondents identify with.From this it is clear that all races identify themselves as South African first, with religion and race in second place, and culture and gender typically third and fourth choices.In order to get more insight on how South Africans describe themselves, an open ended question asked respondents, in five words, to describe themselves, from this it emerges that:People describe themselves in a positive light, focusing on character & personality traits like “loving”, “friendly”, “hardworking”, “respectful” and “honest”.Coincidentally, these self-descriptions match findings from, for example, the Nation Brand Index, and City Brand Index that shows international respondents also describe South Africans as hardworking, open, and friendly people. The images below capture the most common words respondents used to describe themselves.The above self-descriptions can help when speaking about the culture, values, and self-perception of South African people.Media consumption & perceptionsSome general findings from the survey indicate that:It’s top priority among citizens to constantly be informed about happenings in their community and country, as well as supporting local businesses – however when it comes to effort based activities it is deemed as less important.Citizens want easy accessible information provided to them; being most directly influenced by family, friends/ colleagues, followed by mainstream media sources like TV & News radio broadcasts.Having trusted advocates in society that people can learn from and understand – will give more positive outlook about what’s going on in SAThere is consensus that the media portrays more negative than positive information and stories about South Africa. The box below indicates that 62% of respondents think the SA media is too negative about the country.In order to understand the extent to which South Africans trust sources of information, respondents are asked to rate the sources as outlined below.Family, friends & colleagues; TV news; and Radio news are the top three trusted sources of information. Online social networking and related sources of information are the least trusted of all possible sources.Other media consumption factors92% of all respondents own a cell phone;30% of respondents use a laptop;9% of respondents use a tablet.Radio and TelevisionJust over half of the population listen to radio every day with Metro FM, Lesedi FM, and uMhlobo Wenene FM being the most popular radio stations;In terms of television – Movie channels, SABC channels, and Religious channels are the most watched;Documentary and News channels draw about 28% of respondents.Print mediaA quarter of the population read newspapers every day;The Daily Sun is the most read newspaper (34% of respondents read this paper);Other commonly read papers include: Isolezwe (8%); Sunday Times (5%); Beeld (4%); Son (4%); Sowetan (4%); The Citizen (3%).last_img read more

DieMuggels – Genesis (A rough night) – Geocache of the Week

first_imgTo get the treasure, a band of heroes must consist of four brave adventurers. They must brave the terrifying darkness of a foreboding forest on their quest to find the castle. To succeed they need to be equipped with a torch that burns brighter than a campfire, a device that shines black fire, a piece of rope of a precise length — and a special password!This Mystery Cache is located in Switzerland, south-east of Zürich. It is so popular that you need to register your team in advance to secure a spot. After you master the outside stages of this night cache, you will face multiple challenges that require the knowledge of different coordinate systems, logical thinking, intuition, and good team communication.It usually takes a couple of hours to finish this cache and you must solve 15 puzzles in total to sign the logbook. You will face the undead, creatures from ancient times, and you may even encounter a life-size knight!If you are a fan of escape rooms you will definitely enjoy this cache. One ton of gravel, half a ton of wood, multiple electronic devices, and a selection of books were used in the creation of the final.Do you have what it takes to solve the mystery of DieMuggles – Genesis?Continue to explore some of the most amazing geocaches around the world.Check out all of the Geocaches of the Week on the Geocaching blog. If you would like to nominate a Geocache of the Week, fill out this form.Share with your Friends:More Mystery CacheGC6TF2Gby El abnorgollums724 Difficulty:3.5Terrain:2.5 In medieval times, four lords met under the cover of night to devise a plan to hide their treasures from the peasants of the land. One of them used dark magic to transfer all his wealth into the future, where only the most daring adventurers would ever have a chance to find it.center_img Location:Region Zuerich (ZH), SwitzerlandN 47° 23.102 E 008° 41.570 SharePrint RelatedGroundspeak Weekly Newsletter – April 4, 2012April 4, 2012In “Groundspeak’s Weekly Newsletter”Be a better hiderAugust 21, 2018In “News”Enigma #1 – GC448A – GEOCACHE OF THE WEEK – November 8, 2012November 8, 2012In “Community”last_img read more

Microsoft Surface Gains Early Lead Among Windows 8 Devices, Ad Data Indicates

first_imgRelated Posts Role of Mobile App Analytics In-App Engagement Why IoT Apps are Eating Device Interfaces What it Takes to Build a Highly Secure FinTech … Tags:#Microsoft#Surface#Windows 8#Windows Phone Although the data might be a little uncertain, figures released by AdDuplex indicate that Microsoft’s Surface is winning the early race to be the most popular Windows 8/ Windows RT device. At least as calculated by which platforms are acccessing ads on the company’s network.An AdDuplex blog post shows the Surface clearly leading in the tablet and the notebook space, while the Nokia Lumia phones (specifically the older, Windows Phone 7-based Lumia 710) are showing an early lead within Windows Phone. That said, the data also shows Windows Phone 8 capturing 4% of the available Windows Phone views in just a week.However, HP’s PC chief, Todd Bradley, recently told CiteWorld that the Surface is receiving too much hype. “I’d hardly call Surface competition,” Bradley sniffed. “One, very limited distribution. It tends to be slow and a little kludgey as you use it… It’s expensive. Holistically, the press has made a bigger deal out of Surface than what the world has chosen to believe.”“We’re not entering the consumer tablet fray any time soon,” Bradley added, noting that HP does plan to offer a consumer tablet, but not before next year, and most likely a convertible, at that. For now, HP is focused on the enterprise, although it showed off the HP Envy X2 last month. On The Surface, Surface Is WinningBut if the AdDuplex data is to be believed, Bradley’s comments might be seen as spin control. That’s because HP’s own products are just behind the Surface in terms of market share, although a significant gap exists between the two. AdDuplex shows the Surface capturing 11% of all ad impressions, with the HP Pavilion g6 and dv6 notebooks grabbing 2% and 1% of the rest. Far exceeding all of these, however, is the “other” category, with 81% of the totals.  markhachman The enormous “other” category most likely comprises the numerous legacy devices that have been upgraded to Windows 8 as well as generic new PCs  shipped with Windows 8. “Surface is already the most popular single device running Windows 8/RT with 11& of the overall “market”,” AdDuplex said. “That said, we had hits from almost 3,000 different devices running Windows 8 (or Windows RT) in a single day.”With Windows 8 and Surface sales still measured in weeks, not months, it’s difficult to ascribe any real adjectives to describe the success of the Surface launch. AdDuplex didn’t break out the total numbers of impressions; “they are specific to AdDuplex and releasing them would only result in unnecessary speculation,” said Alan Mendelevich, who runs AdDuplex. He also cautioned that ad impressions don’t necessarily correspond to device sales. And, since the company’s network caters exclusively to Windows Phone and Windows 8 apps, it’s difficult to know how Windows 8 products are faring as a whole.That’s a lot of disclaimers, but within the ad sales on Windows 8 this initial data point makes it appears that the Surface is the early winner.Steve Ballmer’s comments to a French-language magazine, in which he reportedly described the Surface tablets as selling “modestly,” was later spun by Microsoft as “in relation to the company’s approach in ramping up supply and distribution of Surface with Windows RT, which has only been available via our online store and Microsoft retail stores in the U.S and Canada,” according to CNET. Instead, Microsoft said, people should think about the Surface launch as what Ballmer has characterized as “fantastic.” More Microsoft Hardware ComingOn stage at the Churchill Club on Monday night, Ballmer used the term “spectacular” to characterize the launch of Windows 8, and talked about how the Surface represented the best of both worlds of tablets and notebook PCs. As for competing against its manufacturing partners, Ballmer acknowledged that Microsoft was “carefully” managing its relationships.“Do I anticipate that partners of ours will build the lion’s share of all Windows devices over the next five years? The answer is, absolutely,” Ballmer said, as quoted by Reuters. “With that said, it is absolutely clear that there is an innovation opportunity on the scene between hardware and software and that is a scene that must not go unexploited at all by Microsoft.” (A full replay of Ballmer’s conversation with LinkedIn founder Reid Hoffman at the Churchill Club is available on fora.tv for $9.95.)Some took that to mean that Microsoft is indeed building a Surface-like version of the Windows Phone. Other interpretations could be that additional Surface revisions could be on the way – whether or not that merely includes the Intel Core-based “Pro” version of the Surface due next year or other hardware is still unknown. What seems to be happening with the Surface is this: Consumers, perhaps unsure of which Windows 8 tablet to buy, have chosen the product, Surface, from the manufacturer that designed the operating system. Is this a case of consumers buying the manufacturer-approved hardware, such as the Google-blessed “Nexus” line of phones or tablets? Microsoft’s huge advertising push? Or some other reason? A Good Start for Windows Phone 8?Apart from Windows 8 and Windows RT, observers are also trying to puzzle out how well Windows Phone 8 is doing. But the AdDuplex data could be skewed because the existing installed base of Windows Phone 7-based hardware should be expected to dominate overall Windows Phone ad impressions. (Again, we have no real sales data for Windows Phone 8 devices at this point.) Four Nokia phones running older versions of Windows Phone – the Lumia 710, 800, 610, and 900 – dominate the impressions, capturing two-thirds of all Windows Phone-based AdDuplex impressions. AdDuplex also reported that it’s difficult to tell what Windows Phone 8 phones have been detected, because of reporting problems with the various Nokia models. But overall, Windows Phone 8 captured 4% of the total Windows Phone impressions in a week, an auspicious start. (Want to know what ReadWrite thought of Windows Phone 8? Here’s a hint: We liked it.) So what does this all mean? If the Surface really does succeed, it will be interesting to see what responses comes from Windows hardware makers. Will they try to outdo Microsoft’s hardware, or back off and try to find a path that doesn’t go head on against the company that supplies the operating they use? On the other hand, if you total up all of the products under a given manufactuer, HP is number one (with 24%), followed by Microsoft (17%). The Rise and Rise of Mobile Payment Technologylast_img read more

6 days agoREVEALED: Why Man Utd teammates mocking Fred

first_imgAbout the authorPaul VegasShare the loveHave your say REVEALED: Why Man Utd teammates mocking Fredby Paul Vegas6 days agoSend to a friendShare the loveManchester United teammates are mocking Fred’s decision to get married during pre-season after he mistakenly thought he would make Brazil’s Copa America squad. The Brazilian midfielder missed the first chunk of United’s summer tour due to his wedding being booked for July.The Times says Fred has been paying the price for his summer gaffe and became the ‘butt of the jokes’.Having booked his wedding for July 14, the Brazilian reportedly had to plead with boss Ole Gunnar Solskjaer to get time off. The 26-year-old midfielder has struggled to live up to his £52m price tag since he joined the club from Shaktar Donetsk in the summer of 2018. last_img read more

Australia political leaders use Chinese app to chase votes

first_imgCanberra: Australia’s prime minister and his political rival said on Wednesday they were not tailoring their political messages to suit Chinese censors as the politicians increasingly use Chinese social media to woo Chinese-speaking voters. Prime Minister Scott Morrison and opposition leader Bill Shorten each have accounts with China’s largest social media platform, WeChat, which they use to target the Chinese diaspora ahead of federal elections on May 18. Also Read – Saudi Crown Prince ‘snubbed’ Pak PM, recalled jet from USCritics argue that the Australian political leaders risk being kicked off the platform if they don’t comply with Chinese censorship rules. Morrison said his account has not been subjected to Chinese censorship used on social media. “We haven’t experienced any such censorship,” Morrison told reporters. Bill Shorten, who leads the center-left Labor Party, was similarly unconcerned by the type of censorship that the Chinese Communist Party routinely exercises on Chinese social media. “I’m not fussed at all,” Shorten told reporters. “I do not feel censored by the Chinese government.” WeChat was launched by Chinese giant Tencent in 2011 and the app, known in China as Weixin, has become essential for daily life in China. Also Read – Record number of 35 candidates in fray for SL Presidential pollsMorrison’s account was registered in January under the name of a Chinese citizen in Fujian province, and Shorten’s account was registered to a Chinese citizen in Shandong province, Australian Broadcasting Corp reported. Morrison said his conservative Liberal Party was trying to transfer his account to Australia. “The way you set up a WeChat account, because of where it’s run, is you have to work through these overseas structures and we’ve been in the process now over the last week or so of seeking to repatriate how that’s done,” Morrison said. Shorten said he left his Labor Party to set up his account. The party said it was set up in early 2017 by an Australian resident who is employed by the party. It is jointly operated by Shorten’s office and the party. “Labor has never experienced any censorship of our communications on any social media platforms,” a party statement said. “We do not tolerate any outside interference that seeks to undermine our free and fair society.” Fergus Hanson, head of the International Cyber Policy Center at the Australian Strategic Policy Institute, said politicians’ use of Chinese social media in the Australian political debate created the possibility of censorship and self-censorship on subjects sensitive to China. “It’s pretty outrageous that you’re in a situation where an Australian politician in a full-blown democracy is being censored in what they can say by the Chinese government trying to speak to other Australians within Australia,” Hanson said. “It’s absolutely preposterous.” Hanson’s own research estimated that there were 1.5 million active WeChat users in Australia including Chinese-speaking Australians, tourists and international students. Australia has a population of 25 million.last_img read more

Domestic Violence Awareness called for by PDM Leader Police extend questioning of

first_img Only Doug and Ralph and Ruth can fit, that’s why Facebook Twitter Google+LinkedInPinterestWhatsApp Recommended for you Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 29 May 2015 – The Leader of the Opposition PDM says she is incensed by the violence being played out against women recently; one of those women dying at the hands of her attacker. Hon Shalene Robinson said the battery of laws recently passed at the House of Assembly, as she put it, “provided greater rights and protection of and for women, parents and children. Among these pieces of Legislation was the Domestic Violence Legislation which secured greater rights and protection and called for greater resources.” Robinson believes, that in light of the two attacks – one a stabbing death, the other a woman lit on fire – there should be a mobilization of relevant agencies to begin “educating women and other persons in domestic relationships on the rights and provisions under this new Bill and also to provide the much needed resources for those who may need practical assistance.” Sharlene Robinson also expressed concern at a home invasion which, she said, “left one of our sisters battered and we are truly saddened by this event as we continue to see a serious change in the way we are used to living in our homeland.” The man police believe responsible for the Monday afternoon stabbing death of a 44 year old Haitian woman has already been to court; but not for formal charges to be laid. The Police got more time to question the suspect from the judge; ten days more. TCI Country Leaders condemn vicious memes Related Items:domestic violence, Hon Sharlene Robinson, Pdm, police TCI Premier blasts Opposition side for “slop” information, sets it straight in HOAlast_img read more