NIAID reports potential West Nile treatment

first_img The researchers decided to develop their treatment, a monoclonal antibody, after they found that antibodies taken from the blood of people who had recovered from West Nile fever could cure mice infected with WNV, the NIAID said. But antibodies derived from human blood vary in their ability to fight disease, and they can be accompanied by other potentially dangerous infectious agents, despite efforts to purify them. See also: To solve these problems, the research team “made 46 monoclonal antibodies against West Nile virus and then eliminated the less effective ones through a tedious molecular-level screening process,” the NIAID said. Then they worked with MacroGenics, Inc., Rockville, Md., to create a human-like version of the most effective antibody. WNV causes no symptoms or only a mild flu-like illness in most people. But in about 1 in 150 people infected, the virus invades the central nervous system and can be fatal. The United States had 2,470 reported cases of West Nile disease in 2004, with 88 deaths, according to the Centers for Disease Control and Prevention. Apr 25, 2005 (CIDRAP News) – Researchers have developed an antibody that can cure mice of West Nile virus (WNV) infection, a disease for which no specific treatment now exists, the National Institute of Allergy and Infectious Diseases announced yesterday. Oliphant T, Engle M, Nybakken GE, et al. Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat Med 2005 Apr 24 (early online publication) [Full text] The research, funded in part by the NIAID, is described in a report published online yesterday by Nature Medicine. “MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody,” the statement said. “The monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection.” A team at Washington University in St. Louis “developed an infection-fighting antibody that mimics one produced by people whose immune systems successfully fend off the West Nile virus,” the NIAID said in a news release. “The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile disease.” “We could give this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them,” senior investigator Michael Diamond, MD, PhD, said in the news release. “It also completely protected the mice against death.” NIAID news releasehttp://www.niaid.nih.gov/news/newsreleases/2005/Pages/westniletherapy.aspxlast_img read more

YouGov releases esports report, states 4 million Brits have watched esports

first_imgThe latest entrant in the world of research reports on esports is international data and analytics group YouGov. This one differs to the likes of Newzoo, Superdata, Nielsen and Juniper however in that it focuses primarily on the UK esports market.In order to contrast and compare, YouGov also surveyed those in Germany, Singapore, China, the US and Australia. The total sample size of the survey was 9,473 and all were aged 18 or over, 2,087 of these were from the UK. China had the highest propensity of those who had watched esports before at 348 out of 1,009. The report, ‘Just a game? Understanding the existing and future UK esports market’, and it’s available to download here. Amongst its findings, the report states that 7% of British adults of those aware of esports, which means close to four million people, have watched some form of competitive video gaming. Perhaps more importantly it found that six in ten of this group (57%) are keen to watch esports again. YouGov’s research covers six markets across the world markets and found that, as expected, younger people are the keenest spectators, with a fifth (21%) of 18-24s in Britain having watched, compared to less than 1% of people aged 55+. One question we have is what the report constituted as esports content, as it mentions that ‘FIFA tops the most watched game’. Whilst content around FIFA is undoubtedly popular especially on YouTube, it lags significantly behind the likes of League, Dota, CS and others when it comes to viewership of its actual esports competitions. The aims of conducting the report are noted as the following; to measure market awareness, to assess the market size and potential market size of esports in the UK and how it compares to other markets, to understand watchers and prospects of esports, to evaluate the role of betting on esports and to size the potential for sponsors of esports. The report also found that the current esports viewers ‘have a greater appreciation than the general public in other areas’. Those who have watched esports are three times as likely as the population as a whole to believe that esports players are athletes, to the tune of 20% vs 6%. In addition, and perhaps in an unsurprising statement, they are around three times as likely to think that esports will become as popular as traditional sports (44% vs. 15%). When it comes to a gender difference, men (at 55%) are notably more likely than women (at 43%) to think competitive video gaming will not replace established sports.YouGov Senior Research Executive Chris Polechonski said: “Even those that review the sport in positive terms are unlikely to see competitive video gaming replacing traditional pastimes, so the onus is on the eSports to industry to allow it to work alongside familiar favourites. Persuading doubters of the sporting merits is a big hurdle as the majority of people do not currently regard eSports as ‘real sport’. However, our research suggests that when people do get round to watching competitive video gaming, their attitudes soften.”Other notable findings include the fact that 7% of those who have watched esports before have bet on it, and 17% of those interested in watching stating they’d be keen to place wagers. The esports betting market is growing at an impressive rate, but still faces some major challenges, which the panel at our August ESI Forum explored. You can watch the video of this here. Esports Insider says: Ignoring the unfortunate capitalised S, this appears a fairly comprehensive report with a survey size of close to 10,000. The fact it’s available for free is also a major plus and kudos to YouGov for this and its UK focus, but our question remains of what constitutes esports content as the report mentions FIFA tops the most watched game. Regardless we’re keen to see more from YouGov which promises that it will continue to monitor and report on the market.last_img read more