NIAID reports potential West Nile treatment

first_img The researchers decided to develop their treatment, a monoclonal antibody, after they found that antibodies taken from the blood of people who had recovered from West Nile fever could cure mice infected with WNV, the NIAID said. But antibodies derived from human blood vary in their ability to fight disease, and they can be accompanied by other potentially dangerous infectious agents, despite efforts to purify them. See also: To solve these problems, the research team “made 46 monoclonal antibodies against West Nile virus and then eliminated the less effective ones through a tedious molecular-level screening process,” the NIAID said. Then they worked with MacroGenics, Inc., Rockville, Md., to create a human-like version of the most effective antibody. WNV causes no symptoms or only a mild flu-like illness in most people. But in about 1 in 150 people infected, the virus invades the central nervous system and can be fatal. The United States had 2,470 reported cases of West Nile disease in 2004, with 88 deaths, according to the Centers for Disease Control and Prevention. Apr 25, 2005 (CIDRAP News) – Researchers have developed an antibody that can cure mice of West Nile virus (WNV) infection, a disease for which no specific treatment now exists, the National Institute of Allergy and Infectious Diseases announced yesterday. Oliphant T, Engle M, Nybakken GE, et al. Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat Med 2005 Apr 24 (early online publication) [Full text] The research, funded in part by the NIAID, is described in a report published online yesterday by Nature Medicine. “MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody,” the statement said. “The monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection.” A team at Washington University in St. Louis “developed an infection-fighting antibody that mimics one produced by people whose immune systems successfully fend off the West Nile virus,” the NIAID said in a news release. “The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile disease.” “We could give this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them,” senior investigator Michael Diamond, MD, PhD, said in the news release. “It also completely protected the mice against death.” NIAID news releasehttp://www.niaid.nih.gov/news/newsreleases/2005/Pages/westniletherapy.aspxlast_img read more

6 Beach Frenchmans Cove Port Antonio Billionai

first_img6. Beach: Frenchman’s Cove, Port AntonioBillionaires used to bathe here. But now that the once uber-luxe Frenchman’s Cove Resort, built in the 1960s, has fallen on harder times, even proles can enjoy one of the loveliest beaches in the Caribbean (albeit for a small fee). The magic is in the setting: a river wends through a jungly valley, pooling in a jade lagoon and tickling out to the turquoise Caribbean via a slither of glimmer-white sand. It feels secluded and special, especially if you stay past sundown, when the fireflies start to party. Jamaica is the Caribbean turned up to 11, an island where palm-and-beach pretty is superseded by history, topography, jerk spice and that beating reggae soul.Bob Marley, Montego Bay, jerk seasoning, sprinting sensations – in many ways, Jamaica feels the realest, most culturally pervasive island of the Caribbean. Certainly, for a tiny nation, it punches well above its weight in terms of global influence – who doesn’t know the words to No Woman, No Cry…? Here’s how to get an authentic taste of this spice-hot isle.1. Freebie: Meet the PeopleTo expand your island interactions, sign up for Visit Jamaica’s free Meet the People Program. It is designed to hook tourists up with local volunteer ambassadors who have similar professions or interests, from musicians and artists to chefs, farmers and nurses. Simply, it’ll give you a better idea of what makes real Jamaicans tick.2. Tour: Tuff GongTuff Gong is the heartbeat of Jamaica. The Kingston-based record label was set up by Bob Marley in 1965, and moved to its current location on Marcus Garvey Drive after his death. The studio still has The Legend’s own piano; its mastering room is where ‘No Woman, No Cry’ came into the world. It is reggae ground zero. An ‘edu-taining’ tour leads from the rehearsal room and recording booth – home to the mixing board used on Marley’s 1970s albums, and still in daily use – to the mastering room, vinyl-stamping plant and hallowed Tuff Gong archives, where a guide can help you select a classic.https://instagram.com/p/zD-XKIKJTF/3. Culture: Last SundaysKingston’s National Gallery of Jamaica is the best showcase of island art: displays range from indigenous Taino carvings and 18th-century oils of slave plantations to modernist sculpture and surrealist canvases. However, on the last Sunday of every month, the gallery is injected with fresh blood, hosting a never-the-same programme of dance, theatre, music, discussion, even yoga; performances sometimes swing leftfield, as the players react to the artworks on the walls.https://instagram.com/p/xKqAlPp92D/4. Activity: Jamnesia Surf ClubIcah Wilmot is Jamaica’s only pro surfer. And though we can’t all slice through a churning barrel with such panache, highlighted dreadlocks splaying in our wake, we can all stay at his place, Jamnesia. The Wilmot family surf-camp is boardy heaven. Beginners can take lessons while amateurs can hire kit, get their kit fixed, bunk down in simple rooms and wait for the right swell in the library, well-stocked with ‘surf porn’.https://instagram.com/p/UuRFQCP8HW/5. Hike: Blue Mountain PeakHandy that the Blue Mountains are so renowned for their coffee – a shot of Joe will be required for this. Expect a wee-hours start (very wee: 2-3am) for an assault on 2,256m Blue Mountain Peak, the island’s zenith. Most hikers hit the trail early to reach the top for sunrise, before the mists start to descend and obscure the view. Descending in daylight reveals the slopes’ full vibrancy: a riot of soapwood trees, mosses, ferns, lianas and bamboo. Related10 tips for travelling the Caribbean on a budgetCaribbean getaways needn’t cost you the earth. These tips and tricks for travelling the Caribbean on a budget mean you’ll still be eating the best jerk chicken, having one rum punch a day and seeing some of the regions most beautiful beaches.8 best things to do in BarbadosYes, Barbados has eye-wateringly beautiful beaches. But there’s far more to this island than some nice sand. The name Barbados is synonymous with ‘beach idyll’, and it does have some stunners. But the island also has a verdant interior, interesting colonial history and exceptionally good food. Turn your back on…Essential guide to 10 of the best Caribbean islandsConsidering a holiday to the paradise islands of the Caribbean? Planning a Caribbean cruise and trying to decide which beaches to hit? Whether you’re booking a family holiday, searching for a dream honeymoon or just wanting sand, sea and rum cocktails, here’s an essential guide to 10 of the best…center_img 7. Adventure: Horseback Ride ’n’ SwimBareback riding into the Caribbean Sea? Well, hot diggity if this doesn’t tap into both your inner romantic and your inner cowboy. Chukka Caribbean’s Horseback Ride ’n’ Swim includes a lazy trot via the village of Pumpkin Bottom and a ruined 18th-century sugar plantation with a saddle-less ride right into the balmy waves.8. Region: Cockpit CountryCockpit Country isn’t ‘the Caribbean’ – not the image most of us are sold, anyway. This chunk of inland western Jamaica is a wild sprawl of eroded limestone, pocked by cone-shaped hummocks and split by gullies. Take a tour with the Southern Trelawny Environmental Agency, an organisation dedicated to protecting and promoting the region. Options include walking the forest trails to learn exotic bird identification and local folklore, and conquering rope climbs and waterfalls to explore inside Quashie Cave.9. Eat: ScotchiesIn Jamaica, be a jerk. That is, eat meat the local way: rubbed with zingy jerk spice, pit-smoked or barbecued, and served with bammy flatbread, fried dumplings or festival (sweet rolls). Scotchies, which has alfresco-dining branches in Montego Bay, Ocho Rios and New Kingston, is no-frills king of jerk; hunks of pork and chicken are machete-hacked and served on foil, while reggae beats mingle with the meat-smoke. Just beware the hot sauce…https://instagram.com/p/1yEBB4rfxf/Hopefully you enjoyed this article. Here are some more you might like:Top 9 things to do in St LuciaTruly a taste of paradise: St Lucia is as scrumptious as the spoils of its cocoa plantations.Top 10 things to do in Trinidad and TobagoThrusting Trinidad stands in stark contrast to laid-back Tobago, but both boast abundant wildlife, beaches, food and fun. Check Jamaica flightsSkyscanner is the world’s travel search engine, helping your money go further on flights, hotels and car hire.ReturnOne wayMulti-cityFromAdd nearby airports ToAdd nearby airportsDepart14/08/2019Return21/08/2019Cabin Class & Travellers1 adult, EconomyDirect flights onlySearch flights Maplast_img read more