The researchers decided to develop their treatment, a monoclonal antibody, after they found that antibodies taken from the blood of people who had recovered from West Nile fever could cure mice infected with WNV, the NIAID said. But antibodies derived from human blood vary in their ability to fight disease, and they can be accompanied by other potentially dangerous infectious agents, despite efforts to purify them. See also: To solve these problems, the research team “made 46 monoclonal antibodies against West Nile virus and then eliminated the less effective ones through a tedious molecular-level screening process,” the NIAID said. Then they worked with MacroGenics, Inc., Rockville, Md., to create a human-like version of the most effective antibody. WNV causes no symptoms or only a mild flu-like illness in most people. But in about 1 in 150 people infected, the virus invades the central nervous system and can be fatal. The United States had 2,470 reported cases of West Nile disease in 2004, with 88 deaths, according to the Centers for Disease Control and Prevention. Apr 25, 2005 (CIDRAP News) Researchers have developed an antibody that can cure mice of West Nile virus (WNV) infection, a disease for which no specific treatment now exists, the National Institute of Allergy and Infectious Diseases announced yesterday. Oliphant T, Engle M, Nybakken GE, et al. Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat Med 2005 Apr 24 (early online publication) [Full text] The research, funded in part by the NIAID, is described in a report published online yesterday by Nature Medicine. “MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody,” the statement said. “The monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection.” A team at Washington University in St. Louis “developed an infection-fighting antibody that mimics one produced by people whose immune systems successfully fend off the West Nile virus,” the NIAID said in a news release. “The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile disease.” “We could give this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them, senior investigator Michael Diamond, MD, PhD, said in the news release. It also completely protected the mice against death. NIAID news releasehttp://www.niaid.nih.gov/news/newsreleases/2005/Pages/westniletherapy.aspx
The Uruguay international took the armband for Sunday’s 5-0 win at Tottenham in the absence of the injured Steven Gerrard and with vice-captain Daniel Agger on the bench. Some questioned whether a player who in nearly three years at the club has had lengthy suspensions for racially abusing Manchester United’s Patrice Evra (seven games) and biting Branislav Ivanovic (10 games), and had tried to force a move away in the summer was deserving of such an honour, especially at a club which had such proud traditions and some exemplary leaders. Liverpool manager Brendan Rodgers believes even Luis Suarez, with his controversial history at the club, deserves a shot at redemption and he had no qualms about naming him as stand-in captain. “I know him well enough and speak with him enough to think he is a great player, a good man and in Stevie’s absence and with Daniel not being in the team I couldn’t think of anyone better to lead the team than Luis Suarez.” Rodgers added: “I think it is part of nature that you mature and the ban hit him really hard last time. “I’ve got to know him as a human being and I know a lot of things written and said about him couldn’t be further from the truth. “He is a really humble man, he just has this unique desire to win games. If you judge him on his football he is up there with the world’s best. “As a human being he’s had his difficult moments and we’ve had our difficult moments with him, but he is a great guy and is really coming to the fore in this period. “He is not only a top player he is one of the pillars of the group. He is maturing, accepting the role and responsibility I’ve given him here. “We are a young side with an average age probably the lowest for a number of years and he has taken on that mantle in order to help and support those young players while having that X-factor to his game.” Suarez is set to lead out Liverpool at Anfield against Cardiff on Saturday. It is a ground where he has scored 12 times in his five appearances this season, goals which have propelled Liverpool not only into the running for Champions League qualification but also title contention as they sit just two points behind Arsenal. Returning to Europe’s elite club competition is likely to be the minimum requirement to keep Suarez at the club. Liverpool have opened preliminary talks over a new, lucrative deal but there is no chance anything would be signed before the club’s fate next season is confirmed. “Contractually with any players it is private so at the minute he is just focusing on his football and there is nothing to report on that (a new contract),” said the Reds boss. “We are just very much focused on improving our performance level and improving players and I think that will all take care of itself, I don’t think there is any rush at this moment in time. “Of course he is a player we want to keep here and build the team around in the coming years.” Gerrard, sidelined until next month with a hamstring injury, is making good progress in his recovery. “Steven is coming along very well, he is outside working and running,” said Rodgers. Bur Rodgers believes the 26-year-old has matured significantly since his most recent ban earlier this year and is keen to give Suarez a chance to make amends. His 17 goals in 11 games to be the leading Premier League goalscorer, firing the Reds into second place, has gone some way to doing that. And with the club desperate to keep the striker – managing director Ian Ayre flew to Barcelona this week to open talks over a new contract – Rodgers will hope any vote of confidence he can give will be reciprocated. “You have seen his performances and conduct,” he said. “Whenever you choose the captain for a team or a club you always analyse lots of things that happen on and off the field. “We all make mistakes and you would hate to think he would be punished for a lifetime because of that. “This is a guy who has made a mistake and what he has shown is he is a learner in response to that. “The award from the supporters (Suarez was voted player of the year by the Football Supporters’ Federation on Sunday), not just those here at Liverpool but throughout the nation who picked him as a top player, in itself, is great redemption for what has happened in the past. Press Association
KINGS XI Punjab climbed into the top half of the VIVO IPL 2019 standings after they defeated the visiting Sunrisers Hyderabad by four wickets at the IS Bindra Stadium in Mohali on Monday night.After winning the toss and opting to field, KXIP executed their bowling plans exceedingly well and restricted the Sunrisers to 150-4.Later in the night, a classy 114-run partnership between KL Rahul and Mayank Agarwal set up the hosts’ run-chase. There was a bit drama towards the end when KXIP lost three wickets for eight runs. KXIP needed 11 off the final over – which was bowled by Mohammad Nabi; Sam Curran and Rahul finished saw KXIP over the line with one ball to spare.Courtesy the dew which had settled down, the pitch had turned batsmen friendly and allowed the Kings XI Punjab batsmen to play their strokes. Chris Gayle perished early, but Rahul and Mayank didn’t let the bowlers dictate terms. Mayank was the aggressor early on, but Rahul wasn’t to be left too far behind. The pair treated Rashid Khan with the respect he deserved, but took on the other bowlers; they added 50 runs in 40 deliveries, and brought up the century partnership 37 balls later.There was a bit of drama in the final few overs when KXIP lost Mayank (55), David Miller and Mandeep Singh in quick succession. But Rahul kept his cool, picked up a boundary off Nabi when his team needed 6 from 3 balls, and then scampered for a brace next ball to take his team home. Rahul finished unbeaten on 71, while Curran contributed 5 crucial runs from the three balls he faced.In the evening, the KXIP took advantage of the muggy conditions; their bowlers started strong – repeatedly bowling disciplined lines and lengths. Even the normally aggressive David Warner was made to work hard for his runs. The left-hander batted the entire twenty overs, made 70 from 62 balls, and guided his team to a modest 150-4.The Sunrisers added 100 runs in the back half – 19 of those runs coming off the last seven balls of the innings.For the hosts, Mujeeb ur Rahman, Mohammed Shami and Ravichandran Ashwin picked up a wicket each.Earlier,David Warner, despite being the aggressive batsman he is, put a price on his wicket, adapted to the conditions and worked hard for his runs – even if it made him look unattractive.The left-hander struggled to cope with the lack of pace on the surface and played out several dot deliveries early on; he crawled to 9 from 17 balls and hit only one boundary in the powerplay period. He brought up his half-century in the sixteenth over – getting there in 49 balls – his slowest ever in the IPL. Warner finished unbeaten on 70; his 62-ball knock contained 20 singles, 10 twos, 6 boundaries and a six.Brief Scores:Kings XI Punjab: 151-4 in 19.5 overs (KL Rahul 71*, Mayank Agarwal 55) defeated Sunrisers Hyderabad: 150-4 (David Warner 70*) by 6 wickets.
JPJ Group terminates InterCasino and Vera&John’s UK presence August 6, 2019 Submit JPJ Group navigates UK headwinds as firm prepares for Gamesys enlargement August 13, 2019 Share Altenar makes Swedish debut through LuckyCasino launch June 17, 2019 Related Articles Former Vera&John Chief Executive Johan Königslehner has stated his intent on joining the upcoming re-regulated Swedish online gambling market, inbound for 1 January 2019.Königslehner is heading up new online gambling outfit Glitnor Group, which this week completed the takeover of LuckyCasino (LuckyCasino.com) from Malta-based operator Viral Interactive for an undisclosed fee.An enterprise founding team member of Vera&John, a European online casino property sold to Intertain Group in 2014 for $130 million, Königslehner seeks to become a lead player in Sweden’s new marketplace.In its market update, the new industry incumbent details that it has drafted a team of experienced industry executives seeking to capitalise on Swedish market developments.“Our team has many years in developing high-growth B2C casino brands such as Vera&John in emerging and mature regulated markets.” Königslehner states on his return to online gambling. “We are tapping into the fast-growing pay and play concept developing in Sweden and Finland with no account creation needed and instant withdrawals. We believe this concept is part of the future and shall be successful in the regulated Swedish market next year.”Taking over Viral Interactive assets, Glitnor Group will maintain the services of CEO Daniel Eriksson as new Head of Business Development.“Being part of building Viral Interactive to where it is and developing the LuckyCasino brand has been a great experience,” Eriksson said. “Joining Glitnor and driving their business development forward in this next period of growth is a challenge that I’m really looking forward to. Share StumbleUpon