NIAID reports potential West Nile treatment

first_img The researchers decided to develop their treatment, a monoclonal antibody, after they found that antibodies taken from the blood of people who had recovered from West Nile fever could cure mice infected with WNV, the NIAID said. But antibodies derived from human blood vary in their ability to fight disease, and they can be accompanied by other potentially dangerous infectious agents, despite efforts to purify them. See also: To solve these problems, the research team “made 46 monoclonal antibodies against West Nile virus and then eliminated the less effective ones through a tedious molecular-level screening process,” the NIAID said. Then they worked with MacroGenics, Inc., Rockville, Md., to create a human-like version of the most effective antibody. WNV causes no symptoms or only a mild flu-like illness in most people. But in about 1 in 150 people infected, the virus invades the central nervous system and can be fatal. The United States had 2,470 reported cases of West Nile disease in 2004, with 88 deaths, according to the Centers for Disease Control and Prevention. Apr 25, 2005 (CIDRAP News) – Researchers have developed an antibody that can cure mice of West Nile virus (WNV) infection, a disease for which no specific treatment now exists, the National Institute of Allergy and Infectious Diseases announced yesterday. Oliphant T, Engle M, Nybakken GE, et al. Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat Med 2005 Apr 24 (early online publication) [Full text] The research, funded in part by the NIAID, is described in a report published online yesterday by Nature Medicine. “MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody,” the statement said. “The monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection.” A team at Washington University in St. Louis “developed an infection-fighting antibody that mimics one produced by people whose immune systems successfully fend off the West Nile virus,” the NIAID said in a news release. “The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile disease.” “We could give this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them,” senior investigator Michael Diamond, MD, PhD, said in the news release. “It also completely protected the mice against death.” NIAID news releasehttp://www.niaid.nih.gov/news/newsreleases/2005/Pages/westniletherapy.aspxlast_img read more

Covid-19: RVP and son Shaqueel showcase impressive skills

first_imgRobin van Persie has been making the most of the coronavirus lockdown by teaching his son a few of his old tricks. The former Arsenal and Manchester United star has been spending his time in isolation taking part in Q&As and he has now taken himself back out onto the pitch. In a video posted to Instagram, Van Persie can be seen lining up on an all-weather pitch at his home with 13-year-old Shaqueel, before the pair of them embark on a rehearsed footwork drill. Robin Van Persie and son Shaqueel making best use of the lockdown The pair, for the most part, managed to keep it synchronised, with Van Persie Jr able to keep up with his old man. Along with the post, the 36-year-old wrote: ‘We’re not the best dancers but put a ball at our feet and… [smugface emoji].Advertisement Loading… ‘Having some fun with Shaqueel van Persie in the garden. Stay safe everyone.’ It has been a busy period for the ex-Holland international, who answered questions about his time at Old Trafford on Tuesday. One story he told about Sir Alex Ferguson caught the eye, as he revealed the wrath two players faced from the Scotsman in the aftermath of heading on an ill-advised night out. Van Persie told SoFoot: ‘The day after the game Sir Alex had photos put up on the dressing room wall of the two players taken during their night out. ‘He told the entire squad: “Boys, if we don’t win the league it’s because of these two a***holes who opted to go out”. Read AlsoPremier League clubs,PFA at loggerheads over pay-cuts ‘I know the names, but can’t reveal them. The manager slaughtered them. It was amazing. He’d put up photos documenting where they were, at 2am, 3am, 4am etc, to underline just how stupid they had been.’ FacebookTwitterWhatsAppEmail分享 center_img Promoted ContentBirds Enjoy Living In A Gallery Space Created For ThemBest & Worst Celebrity Endorsed Games Ever Made7 Universities Where Getting An Education Costs A Hefty PennyCan Playing Too Many Video Games Hurt Your Body?Couples Who Celebrated Their Union In A Unique, Unforgettable WayTop 7 Best Car Manufacturers Of All TimeBest Car Manufacturers In The World8 Things You Didn’t Know About CoffeeWho Is The Most Powerful Woman On Earth?Who’s The Best Car Manufacturer Of All Time?5 Of The World’s Most Unique Theme Parks2020 Tattoo Trends: Here’s What You’ll See This Yearlast_img read more

De Gea credits instinct for stunning stop

first_imgManchester United Man Utd keeper De Gea credits ‘instinct’ for stunning Matip stop Dom Farrell Last updated 2 years ago 22:37 10/14/17 FacebookTwitterRedditcopy Comments() David De Gea Manchester United 2017 Getty Images Manchester United David de Gea Liverpool v Manchester United Liverpool Premier League For the second year running, the Red Devils had to rely on their Spanish shot-stopper to leave Liverpool with a point from a goalless draw Manchester United goalkeeper David de Gea has attributed his stunning save in Saturday’s goalless draw against Liverpool to pure instinct.The Spain international brilliantly kept out Joel Matip’s close-range effort with his foot in the first half to ensure that Jose Mourinho’s side left Anfield with a point.Giroud 7/2 First Goalscorer v Watford Article continues below Editors’ Picks Why Barcelona god Messi will never be worshipped in the same way in Argentina Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. De Gea kept a clean sheet in the same fixture last season by virtue of spectacularly pawing away Philippe Coutinho’s curling effort, but would not be drawn on whether he thought the stop from Matip was better.”I tried to react quickly and sometimes football is so quick,” he told Sky Sports. “At the end I put my foot out and I saved the ball.”It’s instinct to react quickly and try to save the ball.”I don’t know if it’s as good as the one from Coutinho last year. Every save is important, especially at Anfield. It feels good.”FT: Liverpool 0 #MUFC 0. Our unbeaten start to the @PremierLeague campaign continues with a hard-earned point at Anfield. #LIVMUN pic.twitter.com/166M8LtW2J — Manchester United (@ManUtd) October 14, 2017 Manchester United were some distance from their best against the hosts and De Gea admits that Jurgen Klopp’s side were the more dominant side.He added: “We always try to win the game but today I think Liverpool played better than us.”It’s a point away from home so we’re happy.”last_img read more

WWE Supports 12 Charities With New Facebook Watch Show

first_imgWWE today unveiled the 12 charitable organizations paired up with WWE Superstars competing in Mixed Match Challenge, a single-elimination mixed tag-team tournament, where the winning team will receive $100,000 to support their charity of choice.WWE Mixed Match ChallengeMixed Match Challenge is a 12-week tournament that will stream live in the U.S. exclusively on Facebook Watch beginning this Tuesday, January 16 at 10 p.m. ET.“Giving back is in WWE’s DNA and part of our long history, so we are thrilled that each Mixed Match Challenge team will compete to win the grand prize of $100,000 to support organizations that are truly important to them,” said Michelle Wilson, WWE Chief Revenue & Marketing Officer. “This unique and exciting content partnership with Facebook allows us to raise awareness and funds for important initiatives and supports our mission of putting smiles on people’s faces around the world.”Mixed Match Challenge Charities/TeamsIn addition to the $100,000 grand prize, each team’s charitable organization will automatically receive $10,000.The charities and teams include:• AmeriCares helps save lives and improve health for people affected by poverty or disaster. Represented by: Bayley and Elias. • Boys & Girls Clubs of America provides the resources needed to enable all young people, especially those who need them most, to reach their full potential as productive, caring, responsible citizens. Represented by: Jimmy Uso & Naomi. • Connor’s Cure raises awareness and funds for pediatric cancer research, in partnership with The V Foundation and Children’s Hospital of Pittsburgh. Represented by: Alexa Bliss and Braun Strowman. • Girl Up, a United Nations Foundation initiative, inspires and connects girls globally through its leadership program that positions girls to be changemakers in their communities. Represented by: Bobby Roode and Charlotte Flair. • Global Citizen encourages the collective actions of people around the world with the goal of ending extreme poverty by 2030. Represented by: Lana and Rusev. • Hire Heroes USA empowers U.S. military members, veterans and military spouses to succeed in the civilian workforce. Represented by: Alicia Fox and Goldust. • KaBOOM! is dedicated to making sure all kids get the childhood they deserve through great, safe places to play. Represented by: Big E and Carmella. • Make-A-Wish Foundation creates life-changing wishes for children with critical illnesses. Represented by: Natalya and Shinsuke Nakamura. • Rescue Dogs Rock is an animal rescue organization whose goal is to provide homeless, neglected or abused dogs the medical care they need and the loving home they deserve. Represented by: Asuka and The Miz. • UNICEF works in more than 190 countries and territories to put children first and works towards the day when no children suffer from preventable causes. UNICEF USA supports UNICEF’s work through fundraising, advocacy and education in the United States. Represented by: Becky Lynch and Sami Zayn. • Special Olympics is a global inclusion movement using sport, health, education and leadership programs every day around the world to empower people with intellectual disabilities. Represented by: Finn Bálor and Sasha Banks. • Susan G. Komen for the Cure mission is to save lives by meeting the most critical needs in our communities and investing in breakthrough research to prevent and cure breast cancer. Represented by: Apollo Crews and Nia Jax.Facebook Watch is a new platform for shows on Facebook where brands can build and engage with a community of fans. Facebook Watch is available on desktop, mobile and connected TV apps. Fans can follow Mixed Match Challenge to add episodes to their personal Watchlists.last_img read more