NIAID reports potential West Nile treatment

first_img The researchers decided to develop their treatment, a monoclonal antibody, after they found that antibodies taken from the blood of people who had recovered from West Nile fever could cure mice infected with WNV, the NIAID said. But antibodies derived from human blood vary in their ability to fight disease, and they can be accompanied by other potentially dangerous infectious agents, despite efforts to purify them. See also: To solve these problems, the research team “made 46 monoclonal antibodies against West Nile virus and then eliminated the less effective ones through a tedious molecular-level screening process,” the NIAID said. Then they worked with MacroGenics, Inc., Rockville, Md., to create a human-like version of the most effective antibody. WNV causes no symptoms or only a mild flu-like illness in most people. But in about 1 in 150 people infected, the virus invades the central nervous system and can be fatal. The United States had 2,470 reported cases of West Nile disease in 2004, with 88 deaths, according to the Centers for Disease Control and Prevention. Apr 25, 2005 (CIDRAP News) – Researchers have developed an antibody that can cure mice of West Nile virus (WNV) infection, a disease for which no specific treatment now exists, the National Institute of Allergy and Infectious Diseases announced yesterday. Oliphant T, Engle M, Nybakken GE, et al. Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat Med 2005 Apr 24 (early online publication) [Full text] The research, funded in part by the NIAID, is described in a report published online yesterday by Nature Medicine. “MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody,” the statement said. “The monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection.” A team at Washington University in St. Louis “developed an infection-fighting antibody that mimics one produced by people whose immune systems successfully fend off the West Nile virus,” the NIAID said in a news release. “The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile disease.” “We could give this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them,” senior investigator Michael Diamond, MD, PhD, said in the news release. “It also completely protected the mice against death.” NIAID news releasehttp://www.niaid.nih.gov/news/newsreleases/2005/Pages/westniletherapy.aspxlast_img read more

General secretary of faithful Kotoko supporters joins campaign for overhauling of club’s administration

first_imgGeneral Secretary of Faithful Supporters Group of Kumasi Asante Kotoko Kingsley Abeyie says Kotoko need a change in their current administration to oversee a holistic transformation in the processes of the club.Kotoko has come under pressure this very season after failing to perform to the satisfaction in the opening five matches of the league which only intensified after they needed penalties to knock out division two side AK Shion in the MTN FA cup round of 64.“This current administration of the club does not know how to run the club and have failed in terms of administration so therefore we need change in this administration because we are tired with how they are running the club, he told Asempa Sports/“Kotoko can’t only be run by rich men but someone who knows basics in administration and somebody who can properly structure the club.”He however pledged to work behind the scenes to do his utmost best to help the club restore its lost glory.“As for us, we will work underground to help bring change in Kotoko and help support the club as well.” Kotoko play Aduana Stars at Dormaa this weekend with the Porcupines yet to beat the Dormaa side at home since they joined the league in 2009.General Secretary of Faithful Supporters Group of Kumasi Asante Kotoko Kingsley Abeyie says Kotoko need a change in their current administration to oversee a holistic transformation in the processes of the club.Kotoko has come under pressure this very season after failing to perform to the satisfaction in the opening five matches of the league which only intensified after they needed penalties to knock out division two side AK Shion in the MTN FA cup round of 64.“This current administration of the club does not know how to run the club and have failed in terms of administration so therefore we need change in this administration because we are tired with how they are running the club, he told Asempa Sports/“Kotoko can’t only be run by rich men but someone who knows basics in administration and somebody who can properly structure the club.” He however pledged to work behind the scenes to do his utmost best to help the club restore its lost glory.“As for us, we will work underground to help bring change in Kotoko and help support the club as well.”Kotoko play Aduana Stars at Dormaa this weekend with the Porcupines yet to beat the Dormaa side at home since they joined the league in 2009. –Follow Joy Sports on Twitter: @JoySportsGH. Our hashtag is #JoySportslast_img read more

Improved Pass Rates for 18 of 34 Subjects in CSEC

first_img Improved pass rates were recorded for 18 of the 34 subjects sat in the Caribbean Secondary Education Certificate (CSEC) Examination this year. Story Highlights There were 195,498 subject entries of which 188,307 were sat. Of the subjects that were sat, 69.1 per cent were awarded grades 1 to 3.center_img Improved pass rates were recorded for 18 of the 34 subjects sat in the Caribbean Secondary Education Certificate (CSEC) Examination this year.Minister of Education, Youth and Information, Senator the Hon. Ruel Reid, revealed the results of the exam during a press conference at his National Heroes Circle offices in Kingston, on August 18.He noted that overall, the highest increase was in Economics, which recorded an improvement of 12.6 per cent.“There were also increases in the average pass rates for Additional Mathematics (3 per cent); Agricultural Science Double and Single Awards (2.5 and 4.4 per cent); Principles of Accounts (8 per cent); Information Technology (7.3 per cent); Technical Drawing (7.2 per cent) and Theatre Arts (9.3 per cent),” he said.However, there were declines in English B of 13.2 per cent, and Biology, 12 percent, compared with the previous year.The Minister further informed that five subjects had average pass rates of over 90 per cent. These are: Agricultural Science Double Award (96.8 per cent); Agricultural Science Single Award (91.3 per cent); Principles of Business (91.4 per cent); Physical Education and Sport (96.2 per cent); and Food (92 per cent).Turning to Mathematics and English Language, specifically, Mr. Reid noted that these subjects recorded passes of 50.2 and 70.8 per cent, respectively.“When the average attainment rates for Mathematics and English Language were compared with 2016 results, there is a satisfactory movement of 2.5 per cent increase in Mathematics and a little marginal decline in English Language of 0.4 per cent,” he said.A total of 33,799 students sat the exam of the 35,619 that were registered. Sixty seven per cent (22,556) obtained passes at grades 1 to 3. Some 307 more students were registered when compared to 2016.There were 195,498 subject entries of which 188,307 were sat. Of the subjects that were sat, 69.1 per cent were awarded grades 1 to 3.This was a 1.1 per cent increase compared to the previous year.last_img read more

China vows to counter US midrange arms deployment in Asia

first_imgBeijing: China said Tuesday that it “will not stand idly by” and will take countermeasures if the US deploys intermediate-range missiles in the Asia-Pacific region, which Washington has said it plans to do within months. The statement from the director of the foreign ministry’s Arms Control Department, Fu Cong, follows the U.S.’s withdrawal last week from the Intermediate-Range Nuclear Forces Treaty, a move Fu said would have a “direct negative impact on the global strategic stability” as well as security in Europe and the Asia-Pacific region. Also Read – Puducherry on top after 8-wkt win over ChandigarhFu said China was particularly concerned about announced plans to develop and test a land-based intermediate-range missile in the Asia-Pacific “sooner rather than later,” in the words of one US official. “China will not stand idly by and be forced to take countermeasures should the U.S. deploy intermediate-range ground-based missiles this part of the world,” Fu told reporters at a specially called briefing. He also advised other nations, particularly South Korea, Japan and Australia, to “exercise prudence” and not allow the U.S. to deploy such weapons on their territory, saying that would “not serve the national security interests of these countries.” Also Read – Vijender’s next fight on Nov 22, opponent to be announced laterU.S. Defense Secretary Mark Esper said in Asia over the weekend that he wanted to deploy midrange conventional missiles in the Asia-Pacific within months. Australian officials said Monday that the locations for the bases were not yet known but their country would not be one of them. Fu also said China had no intention of joining nuclear weapons reduction talks with the US and Russia, pointing to the huge gap in the size of China’s arsenal compared to those of the other two.last_img read more