NIAID reports potential West Nile treatment

first_img The researchers decided to develop their treatment, a monoclonal antibody, after they found that antibodies taken from the blood of people who had recovered from West Nile fever could cure mice infected with WNV, the NIAID said. But antibodies derived from human blood vary in their ability to fight disease, and they can be accompanied by other potentially dangerous infectious agents, despite efforts to purify them. See also: To solve these problems, the research team “made 46 monoclonal antibodies against West Nile virus and then eliminated the less effective ones through a tedious molecular-level screening process,” the NIAID said. Then they worked with MacroGenics, Inc., Rockville, Md., to create a human-like version of the most effective antibody. WNV causes no symptoms or only a mild flu-like illness in most people. But in about 1 in 150 people infected, the virus invades the central nervous system and can be fatal. The United States had 2,470 reported cases of West Nile disease in 2004, with 88 deaths, according to the Centers for Disease Control and Prevention. Apr 25, 2005 (CIDRAP News) – Researchers have developed an antibody that can cure mice of West Nile virus (WNV) infection, a disease for which no specific treatment now exists, the National Institute of Allergy and Infectious Diseases announced yesterday. Oliphant T, Engle M, Nybakken GE, et al. Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat Med 2005 Apr 24 (early online publication) [Full text] The research, funded in part by the NIAID, is described in a report published online yesterday by Nature Medicine. “MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody,” the statement said. “The monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection.” A team at Washington University in St. Louis “developed an infection-fighting antibody that mimics one produced by people whose immune systems successfully fend off the West Nile virus,” the NIAID said in a news release. “The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile disease.” “We could give this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them,” senior investigator Michael Diamond, MD, PhD, said in the news release. “It also completely protected the mice against death.” NIAID news release read more

Fast reaction: Takeaways from Syracuse’s 30-17 win over Wake Forest

first_img Published on September 12, 2015 at 4:01 pm Contact Sam: | @SamBlum3 Syracuse (2-0, 1-0 Atlantic Coast) shut out Wake Forest (1-1, 0-1) in the second half and overcame a four-point deficit to defeat the Demon Deacons, 30-17, on Saturday afternoon in the Carrier Dome.Running AwayEric Dungey didn’t air it out much in the first half of his first career start. The true freshman quarterback was just 4-of-7 in the first half, while the mostly stagnant Orange offense ran the ball for 73 yards compared to just 35 in the air.Dungey connected on two passes in two of his first three plays, but had just two more the entire rest of the first half. George Morris was the leading rusher, taking six handoffs for 46 yards. Devante McFarlane, who didn’t play last week, averaged just 3.8 yards per carry in the game.In the second half, Dungey flipped the script for the Syracuse offense.AdvertisementThis is placeholder textAn 89-yard sidearm pass to Brisly Estime late in the third quarter shifted the momentum, and was the third longest score in program history. On SU’s next drive, Dungey threw a 21-yard completion down the sideline to Kendall Moore before finding Steve Ishmael for a 53-yard touchdown.Dungey finished with 221 yards on 8-of-13 passing, and added 58 yards on the ground.Defensive resurgenceEven with Syracuse’s two first-half interceptions, the secondary had some major lapses in the Orange’s win. John Wolford started out 20-for-24 in the air and picked apart the Orange defense with a slew of five complete passes in seven plays that spanned just 1:44 of game time.In Wolford’s first touchdown pass, K.J. Brent burned cornerback Julian Whigham, and caught a 40-yard reception before SU’s safeties could close in.Cornerback Wayne Morgan did come up with the big play on the afternoon, when he trucked Isaiah Robinson on a third-and-2 with WFU driving and 4:38 remaining in the game. Two penalties and an Alex Kinal punt later and the Orange coasted to victory.On Wake’s final drive, Antwan Cordy sacked Wolford for a 10-yard loss. Six plays later, Corey Winfield intercepted a pass in the end zone, putting the finishing stamp on a second-half resurgence for SU’s defense.Old SchoolWith Ervin Philips sidelined for the afternoon, Syracuse’s other hybrids were largely non-factors. Ben Lewis had a 17-yard run on SU’s fourth play of the game, but didn’t see the ball again. Dontae Strickland had a 12-yard catch of his own.Philips had two catches — both for touchdowns, and both in the first half — in SU’s season-opening 47-0 win over Rhode Island. But without the sophomore in the game, the Orange’s highly-touted new position played a limited factor in the win. Comments Facebook Twitter Google+last_img read more

NPA, IE Draw Round 5 Encounter

first_imgThe clash produced nearly eight yellow card cautions, with Invincible Eleven receiving five as against three by NPA.The first half ended 0-0 and Invincible Eleven’s Elijah Clark found the opener in the 59th minute following a direct kick.Though there were no corner-kicks in the first half, the second half registered several corner-kicks for both teams that were not utilized to advantage.By the 85th Invincible Eleven’s players had exhibited tiredness, while the NPA players were just starting to attack.It therefore came as no surprise when substitute Weaka Peters hit the equalizer in the 86th minute.From here it was all NPA-Anchors game as Invincible Eleven defended their goal area till the three minutes extra time ended.Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) The NPA Anchors yesterday forced the Invincible Eleven (IE) to a 1-1 draw in their Round 5 league encounter at the Antoinette Tubman Stadium.last_img read more

Apple Answers iPad Pro Bendgate with New Support Doc

first_img Next Tips »» Multitask on the iPad Pro Multitask on the iPad Pro Use Your iPhone as a Hotspot for the iPad Pro Edit Multiple Streams of 4K Video on the iPad Pro Worried about a visible bend in your new iPad Pro? You shouldn’t be, Apple says in a newly posted support document, since it’s just a byproduct of the manufacturing process used for the 11- and 12.9-inch tablets.The new support document, posted late yesterday (Jan. 4), features Apple’s most extensive comments to date on new iPad Pros that came out of their box with a noticeable bend. Last month, some iPad Pro owners reported that their new tablets had a slight though visibly curved chassis – something Apple later confirmed in a few brief public statements on the issue.At the time, Apple said the bend resulted from a cooling process involving the iPad’s metal and plastic parts, and that tablet met Apple’s standards for design and manufacturing. It reiterates those points in the new support document, though with more detail.MacBook Air vs MacBook Pro: Which 13-inch MacBook Is Right For You?Apple’s entry-level MacBook Air and Pro look pretty similar, but our testing proved they differ in crucial ways.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Which Cheap Tablet Is Best? Amazon Fire 7 vs Walmart Onn02:45关闭选项Automated Captions – en-USAutomated Captions – en-USAutomated Captions – en-US facebook twitter 发邮件 reddit 链接已复制直播00:0003:4603:46 Cellular models of the iPad Pro, which seem to be the most prone to this issue, feature small vertical bands that let parts of the tablet’s enclosure act as cellular antennas, Apple says.“In this high-temperature process, plastic is injected into precisely milled channels in the aluminum enclosure where it bonds to micro-pores in the aluminum surface,” the support document reads. “After the plastic cools, the entire enclosure is finished with a precision CNC machining operation, yielding a seamless integration of plastic and aluminum into a single, strong enclosure.”Apple says its flatness specification “allows for no more than 400 microns of deviation across the length of any side,” which the company adds is less than the thickness of four sheets of paper. That’s apparently an even tighter specification than in previous iPad generations.So why the bend? According to Apple’s support document, “the new straight edges and the presence of the antenna splits may make subtle deviations in flatness more visible only from certain viewing angles that are imperceptible during normal use. These small variances do not affect the strength of the enclosure or the function of the product and will not change over time through normal use.”That’s not likely to be of much comfort to new iPad Pro owners who place as much a premium on aesthetics as they do performance. The support document reiterates that Apple has a 14-day return policy on products bought directly from the company, and it instructs iPad Pro owners who think the bend in their tablet exceeds the 400-micron standard to contact Apple Support. Display Two Safari Tabs Simultaneously on the iPad Pro Use the iOS Keyboard as a Touchpad Use Your iPhone as a Hotspot for the iPad Pro Multitask on the iPad Pro Use the iOS Keyboard as a Touchpad Use Your iPhone as a Hotspot for the iPad Pro Display Two Safari Tabs Simultaneously on the iPad Pro Check the Apple Pencil’s Battery Life Check the Apple Pencil’s Battery Life Display Two Safari Tabs Simultaneously on the iPad Pro How to Use the Apple Pencil with iPad Pro’s Notes App Edit Multiple Streams of 4K Video on the iPad Pro Multitask on the iPad Pro Every iPad Pro Keyboard Shortcut You’ll Ever Need Edit Multiple Streams of 4K Video on the iPad Pro Every iPad Pro Keyboard Shortcut You’ll Ever Need How to Use the Apple Pencil with iPad Pro’s Notes App Next Tip »» iPad Pro Tips and Tricks Use the iOS Keyboard as a Touchpad Use Your iPad Pro as a Secondary Display More Tips How to Use the Apple Pencil with iPad Pro’s Notes App Every iPad Pro Keyboard Shortcut You’ll Ever Need Use Your iPad Pro as a Secondary Display ✖ Use the iOS Keyboard as a Touchpad Use Your iPad Pro as a Secondary Display «« Previous Tip Every iPad Pro Keyboard Shortcut You’ll Ever Need Check the Apple Pencil’s Battery Life iPad Pro Tips and Tricks by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GameIf you’re over 40 – this game is a must!Vikings: Free Online GameUndoKelley Blue Book5 Mid-engine Corvettes That Weren’tKelley Blue BookUndoGrepolis – Free Online GameGamers Around the World Have Been Waiting for this GameGrepolis – Free Online GameUndoTODAYPolice Identify Girl Licking Ice Cream Tub In Viral VideoTODAYUndoMy Food and FamilyHealthy, Homemade Drunken Thai Noodles In Just 20 MinutesMy Food and FamilyUndoVerizon WirelessThis new phone will blow your mind.Verizon WirelessUndoAdvertisementlast_img read more