NIAID reports potential West Nile treatment

first_img The researchers decided to develop their treatment, a monoclonal antibody, after they found that antibodies taken from the blood of people who had recovered from West Nile fever could cure mice infected with WNV, the NIAID said. But antibodies derived from human blood vary in their ability to fight disease, and they can be accompanied by other potentially dangerous infectious agents, despite efforts to purify them. See also: To solve these problems, the research team “made 46 monoclonal antibodies against West Nile virus and then eliminated the less effective ones through a tedious molecular-level screening process,” the NIAID said. Then they worked with MacroGenics, Inc., Rockville, Md., to create a human-like version of the most effective antibody. WNV causes no symptoms or only a mild flu-like illness in most people. But in about 1 in 150 people infected, the virus invades the central nervous system and can be fatal. The United States had 2,470 reported cases of West Nile disease in 2004, with 88 deaths, according to the Centers for Disease Control and Prevention. Apr 25, 2005 (CIDRAP News) – Researchers have developed an antibody that can cure mice of West Nile virus (WNV) infection, a disease for which no specific treatment now exists, the National Institute of Allergy and Infectious Diseases announced yesterday. Oliphant T, Engle M, Nybakken GE, et al. Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat Med 2005 Apr 24 (early online publication) [Full text] The research, funded in part by the NIAID, is described in a report published online yesterday by Nature Medicine. “MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody,” the statement said. “The monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection.” A team at Washington University in St. Louis “developed an infection-fighting antibody that mimics one produced by people whose immune systems successfully fend off the West Nile virus,” the NIAID said in a news release. “The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile disease.” “We could give this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them,” senior investigator Michael Diamond, MD, PhD, said in the news release. “It also completely protected the mice against death.” NIAID news releasehttp://www.niaid.nih.gov/news/newsreleases/2005/Pages/westniletherapy.aspxlast_img read more

Virus sets off new school closures in Australia

first_imgMELBOURNE – Australia’s Victoria state has recorded 17 new cases of COVID-19, resulting in the closing of two primary schools in Melbourne. State Premier Daniel Andrews said there would be “significant community transmission” among the new cases. Andrews said one of the new cases was from a person in hotel quarantine, two were from known outbreaks, three were from routine testing and 11 were under investigation. The two schools have been closed for thorough cleaning after students from both schools tested positive for the coronavirus. Victorian State Premier Daniel Andrews addresses a press conference in Melbourne, Australia, Tuesday, June 23, 2020. AP The suburbs where the schools are located are two of six local government hot spots in recent weeks. (AP)last_img read more

‘Padlock’ seals 8th annual Baker’s Memorial Cycling Classic

first_imgBERBICIAN cyclist Andre ‘Padlock’ Green made a welcome return to the top of the podium yesterday when he captured the 8th annual Baker’s Memorial 60-mile cycling classic ahead of a tough field of competitors.Under brilliant sunshine, the cyclists, 38 in total, took off from in front of the Bakers’ residence at the GTT Junction in Linden, took a lap around the mining town before heading down to the turn back point at Moblissa on the Linden/Soesdyke Highway and back to the point of origin for the finish.From the onset, it was clear who would be on the podium as Green, along with Paul De Nobrega, Curtis Dey, Romello Crawford and Briton John quickly established the lead group, leaving the peloton behind.However, it all came down to endurance and an explosive finish on Green’s part; he finished strongly to deny Dey on the backstretch, crossing the finish line with the clock stopped at two hours 33 minutes .83 seconds.Dey, who is known for his power sprint to the death of races, had to settle for second this time around while De Nobrega came in third.Meanwhile, Crawford, Rastaff O’selmo and Briton John were fourth, fifth and sixth, in that order.The race was organised by the Linden Bauxite Flyers Cycling Club and sponsored by Squadra, Clear Waters Inc, Sports Plus and the Baker family and friends.last_img read more

Syracuse closes out Duel in the Desert with 69-55 win over UNLV

first_img Published on December 22, 2017 at 8:36 pm Contact Billy: wmheyen@syr.edu | @Wheyen3 Facebook Twitter Google+ Coming off its first loss of the season on Thursday, Syracuse (12-1) came out firing in the first quarter of its game against UNLV (5-6) on Friday in its final nonconference game. 18-straight points set the Orange out in front from the opening tip and the game was never close in a bounce-back 69-55 win for SU at the Duel in the Desert.The Rebels cut the lead to 14 on the last bucket of the game, but that was the closest the tournament hosts would be to closing on Syracuse after the opening 18-0 run.UNLV struggled with turnovers throughout the contest. The Rebels turned the ball over 28 times, in contrast to Syracuse’s much smaller total of 14. Tiana Mangakahia wreaked much of the havoc for SU, ending the game with eight steals. The turnover margin meant that the Orange was able to attempt 17 more field goals than UNLV in a game which the Rebels barely outshot SU from the floor, 36 percent to 35.8.Gabrielle Cooper, who led the Orange with 22 points in the loss to No. 5 Mississippi State, had another strong scoring output with 17 points. Digna Strautmane had 13 points in the first half and finished with 15 points, seven rebounds and four blocks.Mangakahia finished with 12 points and nine assists, not missing a triple-double by much when combined with her eight steals. Miranda Drummond rounded out Syracuse’s double-digit scorers with a team-leading 18 of her own.AdvertisementThis is placeholder textAt the end of the first quarter, Syracuse led UNLV 28-6. The Rebels outscored SU the rest of the way, winning the last three quarters 49-41. But the big run to start the contest meant that the Orange could breeze to the finish line. A day after losing to the highest-ranked team it will play in the nonconference, Syracuse made sure Friday’s result was never in doubt right from the get-go. Commentslast_img read more