Metaresearchers study how research is done—and why it goes wrong

first_img Policy Forum Toward a more scientific science Given the billions of dollars the world invests in science each year, it’s surprising how few researchers study science itself. But their number is growing rapidly, driven in part by the realization that science isn’t always the rigorous, objective search for knowledge it is supposed to be. Editors of medical journals, embarrassed by the quality of the papers they were publishing, began to turn the lens of science on their own profession decades ago, creating a new field now called “journalology.” More recently, psychologists have taken the lead, plagued by existential doubts after many results proved irreproducible. Other fields are following suit, and metaresearch, or research on research, is now blossoming as a scientific field of its own.For some, studying how the sausage is made is a fascinating intellectual pursuit in itself. But other metaresearchers are driven by a desire to clean up science’s act. Their work has spawned many initiatives to make research more robust and efficient, from preregistering studies and establishing reporting standards to the recent push to make study data freely available for others to explore. Metaresearchers sometimes need a thick skin; not all scientists are grateful when their long-standing practices are questioned. And whether the reforms actually work has become a study object in itself.Metaresearchers are giving their fellow scientists lots of things to think about. But their underlying message is simple: If we understand better what we’re doing, we might be able to do it better. Feature‘Journalologists’ use scientific methods to study academic publishing. Is their work improving science? Feature Meta-analyses were supposed to end scientific debates. Often, they only cause more controversy Feature More and more scientists are preregistering their studies. Should you? Metaresearchers study how research is done—and why it goes wrong Special package: Science under scrutiny Feature This research group seeks to expose weaknesses in science—and they’ll step on some toes if they have to By Martin EnserinkSep. 21, 2018 , 12:05 PMlast_img read more

Kolkata More councillors return from BJP TMC regains 2 civic bodies

first_imgBy Express News Service |Kolkata | Updated: July 14, 2019 2:01:32 am Advertising 4 Comment(s) Kolkata: Kanchrapara municipality 5 councillors return to TMC Best Of Express In undecided Congress, first open call for Priyanka: She should be party chief NRC deadline approaching, families stranded in Assam floods stay home Related News West Bengal Assembly: Two resolutions on ‘rising communalism’ passed by House after a united discussion center_img Advertising kolkata, kolkata mlas, kolkata mlas bjp, kolkata mlas return tmc, kolkata politics, abhishek banerjee, abhishek banerjee on tmc, indian express news Addressing the media, Banerjee said, “After he caused defections, the media described Mukul Roy as the Chanakya of Bengal politics. Now a large number of them have returned to us. (Express photo/Representational)On a day several TMC councillors returned to the party a month after joining the BJP, helping the ruling party in West Bengal to regain Kanchrapara and Halisahar municipalities in North 24 Parganas district and South Dinajpur Zilla Parishad, senior BJP leader Mukul Roy on Saturday claimed that more than 100 MLAs, most of them from TMC, are in touch with the saffron party “Nearly 107 MLAs are in touch with us. Majority of them are from the TMC — a few are from the Congress and CPI(M),” Roy said, without providing details. TMC leader and party Lok Sabha MP Abhishek Banerjee dismissed Roy’s claims.Addressing the media, Banerjee said, “After he caused defections, the media described Mukul Roy as the Chanakya of Bengal politics. Now a large number of them have returned to us. This so-called Chanakya should be described as a Chanakya who is made in China. A leader who cannot hold on to TMC councillors in his party is claiming that more than 107 TMC MLAs are in touch with him…”Banerjee said, “Out of 24 councillors at Kanchrapara, we had 22 councillors, of whom 17 had joined the BJP on May 28. Five councillors had returned earlier, and today nine more have returned. We already had five councillors. After this, we have 19 out of 24 councillors in Kanchrapara — we clearly have the majority and will form the board.” Karnataka: SC to rule today, says Speaker’s powers need relook Section 144 in Bengal town after TMC, BJP workers clash The TMC also regained majority in South Dinajpur Zilla Parishad after three out of 11 TMC members who had defected to the BJP earlier this month returned to the Trinamool. Out of 18 Zilla Parishad seats, the TMC now has support of 11 members, party leaders pointed out.Local BJP leader Suvendu Sarkar said, “Trinamool leaders are using police and administration to force them to return to their party. This will not work forever. More such leaders will join the BJP in the coming days.” Many TMC leaders joined the BJP in the run-up to, and especially after the Lok Sabha polls results. In most cases, the defections were engineered by Roy.Banerjee also maintained that TMC has gained the majority in Halisahar municipality after one more councillor returned to the party. “Out of total 23 councillors in Halisahar, many of our councillors had gone to the BJP. On July 9, 12 councillors returned to TMC and today one more rejoined us. So we have support of 13 councillors out of 23,” he said.Reacting to the development, Roy claimed this “return” to the TMC is a part of his party’s strategy. “This is nothing but a political strategy. Just wait and watch. They might be in TMC, but they will work for BJP…,” he asserted.On July 10, the TMC retained Haringhata municipality in Nadia by registering support of nine councillors in the 17-ward civic body during a no-confidence motion brought by BJP. The no-confidence motion was brought after several TMC councillors pledged their support to the BJP.last_img read more

FDA approves first generic version of commonly prescribed asthma inhaler

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Jan 30 2019The U.S. Food and Drug Administration today approved the first generic of Advair Diskus (fluticasone propionate and salmeterol inhalation powder) for the twice-daily treatment of asthma in patients aged four years and older and maintenance treatment of airflow obstruction and reducing exacerbations in patients with chronic obstructive pulmonary disease (COPD). Mylan obtained approval to market its generic inhaler in three strengths: fluticasone propionate 100 mcg/ salmeterol 50 mcg, fluticasone propionate 250 mcg/ salmeterol 50 mcg and fluticasone propionate 500 mcg/ salmeterol 50 mcg.”Today’s approval of the first generic drug product for one of the most commonly prescribed asthma and COPD inhalers in the U.S. is part of our longstanding commitment to advance access to lower cost, high quality generic alternatives,” said Janet Woodcock, MD, director of the FDA’s Center for Drug Evaluation and Research. “People living with asthma and COPD know too well the critical importance of having access to the treatment they need to feel better. Today’s approval will bring more competition to the market which will ultimately benefit the patients who rely on this drug.”According to the National Heart, Lung, and Blood Institute, asthma is a chronic lung disease that inflames and narrows the airways. Asthma causes recurring periods of wheezing (a whistling sound when you breathe), chest tightness, shortness of breath and coughing. The coughing often occurs at night or early in the morning. Asthma affects people of all ages, but it most often starts during childhood. In the United States, more than 26 million people are known to have asthma, about seven million of these people are children. COPD is a progressive lung disease that makes it hard to breathe and may become worse over time. COPD can cause coughing that produces large amounts of mucus, wheezing, shortness of breath, chest tightness and other symptoms.”The FDA recognizes challenges companies face when seeking to develop hard-to-copy complex generics, such as drug-device combination products, including when the drugs are incorporated into inhalation devices like this,” said Anna Abram, FDA’s Deputy Commissioner for Policy, Planning, Legislation and Analysis. “We are committed to advancing new guidance for sponsors to make the development of generic versions of complex products more efficient, and we’re prioritizing review of many applications covering proposed generic complex products for which a generic has not yet been approved.”Inhalers are known as “combination products” because they consist of a drug and a device. The development of generic combination products can be more challenging than, for instance, solid oral dosage forms, like tablets, and the FDA regularly takes steps to help guide industry through the process. The FDA recognizes the challenges companies face when seeking to develop hard-to-copy complex generics, such as drug-device combination products, including when the drugs are incorporated into inhalation devices.Related StoriesStudy estimates health care costs of uncontrolled asthma in the U.S. over next 20 yearsMultifaceted intervention for acute respiratory infection improves antibiotic-prescribingAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapyUnder GDUFA II, individual companies can meet with the FDA as part of their pre-ANDA program to support their development of such complex products. The FDA also publishes publicly available guidance documents describing the steps the FDA recommends companies take to submit complete, approvable applications for various types of drug products.In 2013, the FDA issued a draft product specific guidance for proposed generic drug products referencing Advair Diskus, which, among other things, provides bioequivalence recommendations, as well as formulation and device considerations. Further, as with brand-name drugs, the FDA inspects manufacturing and packaging facilities for generic drugs to ensure that they are capable of consistently producing quality products.The FDA requires appropriate data and information to demonstrate that complex generic drug-device combination products meet the agency’s rigorous approval standards to ensure quality drug products that are as safe and effective as their brand name counterparts are available to patients.The most common side effects associated with fluticasone propionate and salmeterol inhalation powder for the treatment of asthma include upper respiratory tract infection or inflammation, swelling in the back of the throat (pharyngitis), hoarse voice or trouble speaking (dysphonia), oral candidiasis, bronchitis, cough, headaches, nausea and vomiting. For the treatment of COPD the most common side effects are pneumonia, oral candidiasis, throat irritation, hoarse voice or trouble speaking (dysphonia), viral respiratory infections, headaches and musculoskeletal pain.The FDA continues to advance new policies to promote more generic competition for complex drugs. Recently, the FDA issued 27 guidance documents to help advance the development of generic transdermal and topical delivery systems. The agency also intends to issue an umbrella guidance to help generic drug developers address some of the most challenging regulatory and scientific issues that may be encountered during the development of complex drugs. Source:https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm630151.htmlast_img read more

Study finds neuromelaninsensitive MRI as potential biomarker for psychosis

first_img Source:https://www.nimh.nih.gov/ Reviewed by Kate Anderton, B.Sc. (Editor)Feb 18 2019Researchers have shown that a type of magnetic resonance imaging — called neuromelanin-sensitive MRI (NM-MRI) — is a potential biomarker for psychosis. NM-MRI signal was found to be a marker of dopamine function in people with schizophrenia and an indicator of the severity of psychotic symptoms in people with this mental illness. The study, funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, appears in the Proceedings of the National Academy of Science.”Disturbances affecting the neurotransmitter dopamine are associated with a host of mental and neurological disorders, such as schizophrenia and Parkinson’s disease,” said Joshua A. Gordon, M.D., Ph.D., director of NIMH. “Because of the role dopamine plays in these disorders, the ability to measure dopamine activity is critical for furthering our understanding of these disorders, including how to best diagnose and treat them.”Neuromelanin is a dark pigment created within dopamine neurons of the midbrain — particularly in the substantia nigra, a brain area that plays a role in reward and movement. Neuromelanin accumulates over the lifespan and is only cleared away from cells following cell death, as occurs in neurodegenerative disorders such as Parkinson’s disease. Researchers have found that NM-MRI signal is lower in the substantia nigra of people with Parkinson’s disease, reflecting the cell death that occurs in these patients.Despite the utility of this tool for detecting neuron loss in neurodegenerative illnesses, NM-MRI had not yet been shown to provide a marker of dopamine function, nor had its utility been demonstrated in individuals without neurodegenerative illnesses. In this study, Guillermo Horga, M.D., Ph.D., of Columbia University, New York, and colleagues conducted a series of validation studies to show that NM-MRI can serve as a marker of dopamine function in individuals without neurodegenerative disorders.”The main advantages of this technique are that, compared to other established and more direct measures of dopamine function, neuromelanin-sensitive MRI does not involve radiation or invasive procedures,” said Dr. Horga. “This advantage makes it more suitable for pediatric populations and for repeated scanning, which could be useful to monitor the progression of illness or response to treatment — and it only takes a short scan that could be implemented in most clinical scanners. It also affords a very high anatomical resolution compared with PET measures, which is important to examine functions or dysfunctions of specific parts of the substantia nigra.”The researchers first set out to determine whether NM-MRI could accurately detect regional variations in the concentration of neuromelanin in those without neurodegeneration of the substantia nigra. To examine the detection ability of NM-MRI, the researchers compared NM-MRI measurements of neuromelanin to chemical measurements of neuromelanin in post-mortem brain tissue. The researchers found, across all sections of tissue, that higher NM-MRI signal was associated with higher concentrations of neuromelanin. The results confirm, for the first time, the ability of NM-MRI to measure regional concentrations of neuromelanin. Furthermore, the results show that NM-MRI signal reflects concentrations of neuromelanin in tissue, rather than just the number of neuromelanin-containing neurons.Related StoriesTargeted treatment offers symptom relief for patients with psychosisResearch on cannabis use in women limited, finds new studyNew machine-learning method more precisely quantifies a known indicator for psychosisThe researchers next sought to determine whether NM-MRI could capture variations in neuromelanin in smaller anatomical subregions within the substantia nigra. Since dopamine function is thought to differ significantly in different parts of the substantia nigra, researchers needed to determine the ability of this tool to capture these anatomical differences. So, the researchers examined NM-MRI data from patients diagnosed with Parkinson’s disease and individuals without Parkinson’s disease. The researchers found decreases in NM-MRI signal in those with Parkinson’s disease in the lateral, posterior, and ventral areas of the substantia nigra — findings that correspond to the known anatomical distribution of cell loss in this brain area in Parkinson’s disease. These results confirm that NM-MRI can capture known topographical variability within this brain structure.A next critical step was to show a connection between NM-MRI and dopamine function. The researchers collected measurements of dopamine release capacity (as measured using positron emission tomography (PET)) and NM-MRI data from people without neurodegenerative illnesses. Individuals with a higher NM-MRI signal had greater dopamine release capacity in the striatum (a core component of reward, motor, and cognitive systems). The researchers also found that NM-MRI signal in the substantia nigra was associated with functional MRI measures of regional cerebral blood flow.Lastly, the researchers examined the link between NM-MRI signal and psychosis severity, finding that more severe symptoms of psychosis were associated with higher NM-MRI signals in the nigrostriatal pathway of individuals with schizophrenia and in those at-risk for schizophrenia. Psychosis is associated with dopamine system dysfunction, characterized by greater dopamine release and synthesis capacity in the striatum. The findings suggest that NM-MRI is capturing this dopamine dysfunction, supporting the role of NM-MRI as a potential biomarker for psychosis.The findings reported in this study, taken together, validate the use of NM-MRI in populations beyond those with neurodegenerative disorders, showing it can serve as a measure of neuromelanin concentration and dopamine function in the substantia nigra.In describing the future directions of their research, Dr. Horga said, “We are now extending this work to see if we can detect abnormalities in neuromelanin signal that help us predict which individuals are more likely to develop a psychotic disorder among those who already show early symptoms of psychosis. We are also interested in exploring whether neuromelanin-sensitive MRI could be used in the future to determine who might best benefit from dopaminergic treatments.”last_img read more

HORIBA Medical introduces DDimer reagent for Yumizen G hemostasis range

first_img Source:http://www.horiba.com/uk/medical/news-events/news/article/horiba-medical-launches-d-dimer-reagent-for-yumizen-g-haemostasis-range-59415/ Mar 25 2019HORIBA UK Ltd, Medical announces the launch of a D-Dimer parameter for its Yumizen G hemostasis range of instruments. The new Yumizen GDDi 2 (D-Dimer) reagent kit is now available for HORIBA Medical’s hemostasis instrument range which includes the compact Yumizen G200 coagulation analyzer (pictured).Related StoriesHORIBA Medical’s new HELO fully automated hematology platform installed at Torbay HospitalStudies show HORIBA’s new hematology analyzer improves POCT and care of oncology patientsHORIBA Medical introduces new Yumizen G range to extend Hematology portfolioThe new Yumizen G DDi 2 (D-Dimer) reagent kit offers a key measurement and reference exclusion test for the diagnosis of deep vein thrombosis (DVT) and pulmonary embolism (PE). It can also be used for monitoring the progress and effectiveness of treatment of Disseminated Intravascular Coagulation (DIC).HORIBA Medical’s new D-Dimer reagent kit is available for its full range of coagulation instruments which covers the needs of any laboratory. The dedicated hemostasis portfolio includes the fully automatic Yumizen G800, Yumizen G1500, and Yumizen G1550, as well as semi-automatic Yumizen G200 and Yumizen G400 analyzers. Using antibody-coated latex particles and measured via the immuno-turbidimetric channels of these Yumizen G instruments, the new reagent kit delivers D-Dimer results consistency across the range.The D-Dimer assay when used on very compact coagulation screening platforms such as the Yumizen G400DDi and Yumizen G200, which also have combined immuno-turbidimetric and chromogenic assay capabilities, is particularly ideal for small laboratories, hot labs and as a backup.On these semi-automatic systems, the Yumizen G DDi 2 reagent kit offers an innovative combination of immuno-turbidimetric test capability and pre-calibrated ready-to-use reagent.Offering a cost-efficient solution, the new assay minimizes preparation time due to its ready-to-use liquid format. Furthermore, as the reagent is pre-calibrated it removes the need for a costly and time-consuming calibration step. Its high stability and optimized volume packaging also avoids wastage.HORIBA Medical’s new D-Dimer test kit is fully compliant with Gold Standard performances, having a Negative Predictive Value of 99% and an absence of hook effect up to 25 µg FEU/ml. It also offers slope check and post dilution function on both fully automatic and semi-automatic systems with a cut-off value at 0.5 µg FEU/ml.last_img read more

Scientists discover trigger region for absence epileptic seizures

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Apr 25 2019Scientists have discovered a neurological origin for absence seizures–a type of seizure characterized by very short periods of lost consciousness in which people appear to stare blankly at nothing. Using a mouse model of childhood epilepsy, a team led by Kazuhiro Yamakawa at the RIKEN Center for Brain Science (CBS) in Japan showed that absence epilepsy can be triggered by impaired communication between two brain regions: the cortex and the striatum.Epileptic seizures come in several varieties. Most are familiar with tonic-clonic seizures, which are characterized by large convulsions. However, several kinds of childhood epilepsy are characterized absence seizures in which children experience widespread erratic brain activity that leaves them unconscious for a number of seconds, but without any convulsions. Absence seizures are associated with spike-wave discharges (SWDs)–irregular brain activity that can be recorded on electrocorticograms. While some medications are available, a clearer understanding of how these types of seizures begin in the brain will lead to the development of better therapies.Because children with these types of epilepsy often have mutations in the STXBP1 or SCN2A genes, scientists have created mouse models of these childhood epilepsies by mutating these genes. For both genes, the team at RIKEN CBS created mice with one normal gene and one mutated gene–a condition called haplodeficiency, which is different from a complete knockout. After establishing that their mice experienced absence seizures, as evidenced by SWDs over the somatosensory cortex, they performed a series of experiments to determine how they were triggered.Related StoriesAn active brain and body associated with reduced risk of dementiaNeural pathways explain the relationship between imagination and willingness to helpNanoparticles used to deliver CRISPR gene editing tools into the cellSWDs can be blocked by drugs than inhibit neurons from exciting each other. The scientists injected a neuronal inhibitor into several brain regions hoping to find which ones were related to the seizures. They found three regions: somatosensory cortex, the thalamus, and a part of the striatum beneath the cortex. Although many have thought that the thalamus and the somatosensory cortex are the primary sources for absence seizures, further experiments showed that the region critical for triggering the seizures was actually in the striatum.After finding that injecting a neuron-exciting drug only into the striatal region of the model mice reliably induced SWDs, they created mice with mutations limited to only neurons in the somatosensory cortex that were connected to the striatum. These mice showed the same SWDs, meaning that absence seizures were triggered by faulty signals arriving in the striatum. An additional experiment showed that the problem arose because transmission specifically to fast-spiking interneurons in the striatum was too weak.These findings were somewhat unexpected. As Yamakawa explains, “although the cortico-thalamic circuit has long been assumed to be the sole and exclusive causal source for absence epilepsy, we showed that it is actually triggered by impaired cortico-striatal excitatory transmission. This could be a paradigm shift for epilepsy research.”As effective therapy for epilepsy depends on understanding the exact mechanisms through which seizures are generated, these findings will guide drug development in new directions that might prove more effective than today’s treatments. Source:http://www.riken.jp/en/last_img read more

Sociodemographic factors polysubstance use linked with opioidrelated overdose deaths

first_imgAs a provider, these findings indicate a pressing need to address and treat not just opioid use disorder, but other substances that patients are misusing.”Lead author Joshua Barocas, MD, infectious disease physician at BMC and assistant professor of medicine at BU School of Medicine Reviewed by James Ives, M.Psych. (Editor)May 30 2019A new study led by Boston Medical Center’s Grayken Center for Addiction shows that opioid-related overdose deaths involving another substance is now the norm, not the exception, in Massachusetts. The researchers analyzed opioid overdose death data from the Massachusetts Department of Public Health, which showed that 82 percent of those deaths involved an opioid and another substance, including stimulants. Of importance, the researchers also identified specific sociodemographic factors and social determinants of health associated more with polysubstance opioid-related overdose deaths.Published in Drug and Alcohol Dependence, the findings indicate a pressing need to address the social barriers impacting patients with substance use disorder who are using multiple substances, such as homelessness, mental health issues, and addiction treatment for those who are incarcerated, in order to reduce polysubstance use and subsequent overdose deaths.Polysubstance use, or using more than one substance at a time, has become increasingly common in individuals with opioid use disorder. While previous research has looked at opioid overdose deaths and social determinants of health broadly, there have not been studies looking at polysubstance versus non-polysubstance overdose deaths and the social factors associated with those deaths, which this study looked to uncover.BMC collaborated with the Massachusetts Department of Public Health and analyzed opioid-related overdose deaths in the state from 2014 to 2015 using data from the Massachusetts Public Health Data Warehouse, which links data from various state agencies at the individual level. They examined postmortem toxicology data to identify the drugs present at the time of death and grouped into three categories – opioids only; opioids and other substances not including stimulants; and opioids with stimulants, with or without other substances.During the two year period studied, there were 2,244 opioid-related overdose deaths in Massachusetts with toxicology results available. Seventeen percent of those deaths had only opioids present, 36 percent had opioids and stimulants (primarily cocaine), and 46 percent had opioids plus other substances, but not stimulants. The data also indicated that individuals over the age of 24, non-rural residents, those with co-morbid mental illness, non-Hispanic black residents, and those with recent homelessness were more likely to have opioids and stimulants, such as cocaine or methamphetamine, in their systems at their time of death than opioids alone. Related StoriesUTHealth researchers investigate how to reduce stress-driven alcohol useGoing teetotal shown to improve women’s mental healthTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTThe challenge, he says, is that while there are FDA-approved medications to treat opioid use disorder, there are not effective medications to treat other substances, such as cocaine or amphetamines.Additionally, the data clearly shows that untreated mental illness and social determinants of health are risk factors for overdose death. Specifically, those who are homeless or have mental illness are more likely to use opioids and stimulants, and more work is needed to identify ways to better engage these individuals in care. “To truly make a difference in reducing opioid overdose deaths, we must tackle issues such as homelessness and access to mental health services. This means not only investing in treatment but also implementing tailored programs that address the specific barriers to accessing care.”Source:Boston Medical CenterJournal reference:Barocas, J.A. et al. (2019) Sociodemographic factors and social determinants associated with toxicology confirmed polysubstance opioid-related deaths. Drug and Alcohol Dependence.  doi.org/10.1016/j.drugalcdep.2019.03.014last_img read more

FDA approves antibacterial drug to treat complicated urinary tract infections intraabdominal infections

first_imgRelated StoriesAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapySchwann cells capable of generating protective myelin over nerves finds researchStudy: Surveillance for antibiotic-resistant bacteria continues to be core focus for healthcare facilitiesRecarbrio is a three-drug combination injection containing imipenem-cilastatin, a previously FDA-approved antibiotic, and relebactam, a new beta-lactamase inhibitor.The determination of efficacy of Recarbrio was supported in part by the findings of the efficacy and safety of imipenem-cilastatin for the treatment of cUTI and cIAI. The contribution of relebactam to Recarbrio was assessed based on data from in vitro studies and animal models of infection. The safety of Recarbrio, administered via injection, was studied in two trials, one each for cUTI and cIAI. The cUTI trial included 298 adult patients with 99 treated with the proposed dose of Recarbrio. The cIAI trial included 347 patients with 117 treated with the proposed dose of Recarbrio.The most common adverse reactions observed in patients treated with Recarbrio included nausea, diarrhea, headache, fever and increased liver enzymes.Recarbrio should not be used in patients taking ganciclovir unless the benefits outweigh the risks as generalized seizures have been reported. Patients should also avoid using Recarbrio when taking valproic acid or divalproex sodium, drugs used to manage seizures, as a reduction in valproic acid level may lead to seizures.Recarbrio received FDA’s Qualified Infectious Disease Product (QIDP) designation. The QIDP designation is given to antibacterial and antifungal drug products intended to treat serious or life-threatening infections under the Generating Antibiotic Incentives Now (GAIN) title of the FDA Safety and Innovation Act. As part of QIDP designation, Recarbrio was granted Priority Review under which the FDA’s goal is to take action on an application within an expedited time frame.The FDA granted the approval of Recarbrio for the treatment to Merck & Co., Inc.A key global challenge the FDA faces as a public health agency is addressing the threat of antimicrobial-resistant infections. Among the FDA’s other efforts to address antimicrobial resistance, is the focus on facilitating the development of safe and effective new treatments to give patients more options to fight serious infections. Source:U.S. Food and Drug Administration The FDA remains focused on facilitating the development of safe and effective new antibacterial drugs to give patients more options to fight serious infections. It is important that the use of Recarbrio be reserved for situations when there are limited or no alternative antibacterial drugs for treating a patient’s infection.”Ed Cox, M.D., M.P.H., director for the Office of Antimicrobial Products in FDA’s Center for Drug Evaluation and Research Reviewed by James Ives, M.Psych. (Editor)Jul 17 2019The U.S. Food and Drug Administration has approved Recarbrio (imipenem, cilastatin and relebactam), an antibacterial drug product to treat adults with complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI).last_img read more

Netflix lifted by beautiful quarterly report

Citation: Netflix lifted by ‘beautiful’ quarterly report (2018, January 23) retrieved 18 July 2019 from https://phys.org/news/2018-01-netflix-beautiful-quarterly.html Netflix has been on a tear with original programs such including “The Crown” and “Stranger Things.”Netflix shares hit a record high during the trading day, with a leap after the earnings release lifting the California-based company’s overall value above $100 billion for the first time.In its fourth quarter report, Netflix said it added 8.3 million new subscribers to bring its total paid membership base to 110.6 million.Net profit in the quarter surged to $186 million from $67 million a year earlier as the leader in streaming video saw growth ramp up in many parts of the world. Revenue for the quarter rose 33 percent to $3.3 billion.”We had a beautiful Q4, completing a great year as internet TV expands globally,” said a Netflix letter to shareholders with the quarterly report.”In 2017, we grew streaming revenue 36 percent to over $11 billion, added 24 million new memberships (compared to 19 million in 2016), achieved for the first time a full-year positive international contribution profit and more than doubled global operating income.”As it has shifted more to original content, Netflix has been winning awards for its shows and has helped shake up both the television and film industries with its deep pockets.By delivering online, Netflix is available in some 200 markets worldwide, with the goal of being a global TV network, and now produces programs in several languages.Netflix said it expects to spend between $7.5 billion and $8 billion on content for 2018.”We believe our big investments in content are paying off,” the statement said.”In 2017, average streaming hours per membership grew by nine percent year-over-year.”During an “interview” style earnings call—a change of pace for Netflix—chief executive Reed Hastings and other executives were heavily questioned about how spending on shows weighs on profit.”We are choosing a business strategy that essentially has us take all of our domestic profit and put it into international expansion,” Hastings said.”We think that is the right move, but it definitely takes a strong stomach on the part of investors.”He noted that Netflix is “very comfortable” with its current subscription price as well as its tactic of putting global expansion over short-term profit.”Our content is getting better; our service is getting better,” Hastings said.”Of course, the larger we get the harder it is to grow, and the more time that goes by the better our competitors get.” © 2018 AFP Netflix shares jump as subscriptions top 100 million Netflix shares raced higher in after-hours trade Monday as the streaming television giant reported better-than-expected gains in its global subscriber base and a quarterly profit that nearly tripled from a year ago. Netflix reported strong gains in profits and subscribers in what it called a “beautiful” fourth quarter Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Whats really driving the future of retail

first_img The challenge with specific predictions is that these are susceptible to becoming obsolete fast. Future technologies are likely to make the current cutting-edge redundant, and the methods by which customers can customise products are likely to look very different in the future. However, when you take a step back, some common themes emerge from these predictions, such as convenience, customer experience, business intelligence, and personalisation. It’s these themes that will really shape the future of retail.Many specific predictions about the use of new technologies, for example, link back to the notion of providing convenience to shoppers, or learning more about customers. Predictions relating to the rising use of data and analytics are about becoming more intelligent in interactions with customers.While the specifics of each theme may change, their impact is likely to stay. For example, convenience in the future may relate to payment technologies, store opening hours, or other as yet unknown methods. Whatever the case, the drive for convenience is likely to persist.While some themes are easily identified, others are less obvious; including fragmentation, flexibility, and transparency. FragmentationAt a population level, PWC describes fragmentation as the widening gap between the “haves” and the “have nots” and the impact this has had on consumer behaviour. Similar fragmentation is driving the future of the retail industry in a number of ways. A common prediction is that retail space (including stores and centres) will become smaller. Yet some retailers are opening new flagship stores and some already large centres have been expanded. This article was originally published on The Conversation. Read the original article. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Many predictions about the “future of retailing” have been made. These range from the supposed dominance of certain technologies, to increased use of data and analytics, the rising need for personalisation and customisation, and the transformation of physical spaces. Fragmentation is also occurring at the retail level. Mega-retailers like Amazon and Alibaba are holding strong positions in many markets. At the same time small, niche and independent retailers are gaining exposure through outlets such as Etsy and 100 Squared. The major question arising from this theme is what will happen to the middle? Already department stores like Myer have struggled to find a place. They lack the range and scope of the largest retailers, but don’t have the independence and flexibility of niche operators.FlexibilityFlexibility is about retailers adapting to changing trends and consumer demands. This is clearly seen in current trends and future predictions related to personalisation and customisation.Allowing customers to customise products requires flexibility to adapt product or service offerings. At the same time, more flexibility is expected with physical spaces. Traditional large store footprints are giving way to small and flexible showrooms. A new format of “super-neighbourhood” shopping centre is expected to focus on flexibility for local communities. This theme has interesting implications for the future. How can stores and shopping centres be designed and managed to provide flexibility? How will the need for flexibility impact the already challenging relationships between retail tenants and landlords? Finally, how far can flexibility in product and service design really go? Will retailers of the future be able to let consumers design anything they want with no boundaries? TransparencyThe idea of transparency has gained a lot of attention with discussions about Facebook and Cambridge Analytica. However, a similar theme is impacting retail. Consumers have unprecedented access to information about stores, brands and products through online channels, mobile devices and consumer-to-consumer sharing. This challenges retailers to be transparent and honest with product or service offerings, as misrepresentations are easily identified. How can retailers best manage the need for transparency while still maintaining a competitive advantage? Alternatively, should retailers and shopping centres look to discourage consumer information-gathering? Or can transparency be leveraged to create mutual benefit for consumers and retailers?What next?Australian retailers have had a tough time in recent years. Online shopping is growing steadily and major international companies like Costco are also expanding. This has turned retail into a global competition.No-one really knows what the future will hold, as confident as some predictions may sound. However, considering the underlying drivers of current trends, as well as future predictions, there are some key factors to consider. The real value comes not from focusing on only one driver, or the latest buzz trend. It is important to consider how these multiple trends overlap. For example, providing more flexible services might help satisfy the need for greater customer experience, as well as convenience. Alternatively, greater transparency might help cope with the fragmentation of the industry. The challenge for the retail industry is to develop specific strategies for the future based on these driving forces. Consumers trust supermarkets more than online giants, new research showscenter_img Provided by The Conversation Citation: What’s really driving the future of retail? (2018, July 30) retrieved 18 July 2019 from https://phys.org/news/2018-07-future-retail.html What is the future of retail? Credit: Shutterstock Explore furtherlast_img read more

New defence against superbug infections

first_imgTiny implanted 3-D printed scaffolds infused with antibiotics could revolutionise the way doctors prevent deadly ‘superbug’ infections post-surgery, saving lives and long hospital stays. QUT Institute of Health and Biomedical Innovation biomedical engineer Dr. Phong Tran said insertion of any foreign body whether an implant or a prosthesis such as a hip joint was recognised as a major contributing factor to infections by the bacteria Staphylococcus aureus known as “golden staph”.”Some of these bacteria have evolved into a ‘superbug’ due to exposure to sub-therapeutic levels of antibiotics,” said Dr. Tran, from QUT ARC Industrial Transformational Training Centre in Additive Biomanufacturing.”My research has found a new way to use antibiotics on a biodegradable scaffold which could be delivered inside the body at the surgery site by the surgeon as a promising way to prevent golden staph infection and its development of resistance to antibiotics.”This could allow surgeons to implant pre-made scaffolds with antibiotics in the operating theatre, which are personalised to specific patients and surgical scenarios.”Dr. Tran said this new approach could be used for other bacteria such as E-coli and Pseudomonas aeruginosa which are often found in infected implants, such as new hip joints, and prostheses. “The current method of preventing these infections is intravenous antibiotics before and after surgery or the insertion of antibiotic-containing beads during the operation.”Another traditional method is to mix antibiotic powder and polymers or ceramics before manufacturing the mixture into cement or implants to be inserted in the body.”The problem here is that many commonly used antibiotics have reduced activity when exposed to elevated heat or harsh solvents during this manufacturing process.”Our technique solves all these problems because these antibiotics will retain their full strength when they are drop-loaded from their solution on already-made scaffolds.”Dr. Tran said the research showed a promising strategy for increasing patient surgical safety and is being tested in more complex physiological-like conditions such as 3-D engineered human tissue which other members of the QUT ARC Transformational Training Centre in Additive Biomanufacturing have developed.The research was published in Materials Science and Engineering C. “Our laboratory research, using Cefazolin a common antibiotic against golden staph, has shown these scaffolds release active antibiotic for four days killing off the bacteria.”Dr. Tran said that although Staphylococci aureus and Staphylococcus epidermis were common on patients’ skin they could be deadly when they got inside a surgical wound.”What happens is that these bugs form bacterial biofilms on the surface of the implant that protect the newly embedded bacteria from the body’s own immune system, and systemic antibiotics have only very low efficiency against them,” he said. Credit: Queensland University of Technology Tiny antibiotic beads fight infections after joint replacement Credit: Queensland University of Technology More information: Luke E. Visscher et al. 3D printed Polycaprolactone scaffolds with dual macro-microporosity for applications in local delivery of antibiotics, Materials Science and Engineering: C (2018). DOI: 10.1016/j.msec.2018.02.008 Provided by Queensland University of Technology Citation: New defence against ‘superbug’ infections (2018, September 13) retrieved 17 July 2019 from https://phys.org/news/2018-09-defence-superbug-infections.html “The tiny micropores hold the antibiotic in the scaffold so it can be slowly released into the infection site.”The larger macro-pores are there to support the infiltration of the body’s tissue into the scaffold to keep it in place while the life-saving antibiotics are released directly into the surgical site. Credit: Queensland University of Technology “When patients have an infection at an implant site, surgeons often do ‘revision surgery’ to ‘clean out’ the infection,” he said.”This new technique could allow them to tailor the type of antibiotics and doses for the specific infection and deliver it directly at the infection site, therefore it would be highly effective.””The scaffolds, too, would be made personalised to the specific surgical site and procedure.”Dr. Tran said the new 3-D scaffolds were printed with a biodegradable, medical-grade, FDA-approved polymer, and antibiotics were added by simply soaking the scaffolds in antibiotic solutions.”These scaffolds have both micro-pores and macro-pores in them,” he said. Explore further Credit: Queensland University of Technology This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Mobile apps might make you feel better about travelling alone but they

first_imgThe bSafe app allows your loved ones to pinpoint your location when you activate the SOS button. Credit: BSafe Explore further There are a wide variety of smartphone apps that certainly make travelling alone easier to navigate. Think offline maps, language translation, transport timetables, online ticket bookings, Uber, electronic banking, virtual private networks (VPNs, especially if using electronic banking on public Wi-Fi), and updating friends and family about one’s activities. Then there are the more specific “safety” technologies. Some of them, like the Australian government’s Smart Traveller website, allow voyagers to register their intended whereabouts in case of a natural disaster or emergency. Travellers can also keep up to date with local risk and incident alerts, which can help you to steer clear if there is an incident in the city you’re headed to. Others, like BSafe and Bugle, allow you to easily notify your emergency contacts if you feel unsafe, or do not arrive at your intended destination.But while these apps might make you feel safer, it doesn’t necessarily follow that they make you safer in reality.How risky is solo travel for women?In Australia, one in three women has experienced physical violence since the age of 15, and one in five has experienced sexual violence. Much of this violence takes place in private space. And the overwhelming majority of it is committed by men who are known to the woman victim. Often by an intimate partner, date, family member or acquaintance. The rates and patterns of violence against women are similar in many countries globally. But there are some places where both violence generally, and violence against women, happen more frequently and where travellers might be at additional risk. For example, a 2013 report of the World Health Organisation found that women in Africa were almost twice as likely as women in Europe to experience violence. Meanwhile the Australian government recommends avoiding any travel to some countries and regions within Africa, South America and the Middle East. India also features in research into countries which may be comparatively less safe for women travelling alone.But for many of the most common destinations of Australians travelling overseas, the rates and patterns of violence against women are similar to those at home. Some countries, such as Japan, have notoriously low rates of sexual violence. Although there are also well documented concerns over sexual harassment on the subway, and some claims of substantial under-reporting of sex crimes due to social taboos. Yet the point remains that statistically speaking, unless you’re travelling to a high conflict zone or your travel is to seek refuge in another country, then as a woman it is not necessarily “riskier” for you to travel solo abroad. This doesn’t mean that there is no risk, but generally speaking the risks of sexual assault or homicide from an unknown male perpetrator in a public place are low. Many women do experience street harassment, intimidation and fear from men in public, but this happens in Australia as well as abroad.’Security theatre’Women are experienced at different types of “safety work”. Many women take additional precautions to manage both their risk of violence, and their feelings of fear or safety, on a daily basis. From avoiding eye contact with unknown men in the street, to wearing headphones even without music playing, to sitting in the back seat of a taxi, to texting a friend when we are home safe. While travelling solo, this safety work might also include: providing family or friends with our itinerary before we depart, regularly checking in our location on our social media, sending location updates or any changed plans back to family or friends back home, and following along on our navigation while taking a taxi. Of course, some of these activities – which are certainly practical – can also be understood as managing fear, rather than necessarily keeping us safer. Some of them are directed only at raising the alarm should we go missing – that is presumably, after some harm has already befallen us. We engage in a kind of “security theatre” – a term famously used to refer to some counter terrorism measures that actually do little to reduce the risk of a terrorist attack, but make the public less afraid. For women, our security theatre includes practices that make us feel safer and more empowered to enter into public spaces. The right amount of panicAs legal scholar Fiona Vera-Gray rightly points out, it seems impossible to know what “the right amount of panic” is. Women are regularly blamed if they fall victim to men’s violence for not being panicked enough – in other words, for taking too much risk. But if we are too panicked it will restrict our movements and participation in the world in ways that seriously undermine our freedoms. To travel solo while female seems to require walking a tightrope of challenging gender stereotypes of women as inherently in danger and in need of protection, while also navigating a cascade of advice on how to keep safe. Ultimately, of course, no mobile app is going to prevent a violent crime by a perpetrator who chooses to enact it. But if the convenience of an all-in-one navigating, translating and incident reporting device both makes solo travel easier – and makes you feel more safe and confident – then go on, get out there! Provided by The Conversation As I was writing this article, I was fortunate enough to be at a conference in Florence, Italy. Like a growing number of women who travel overseas, whether for work or leisure, many of the trips I’ve done in recent years have been alone. And as a digital criminologist (as well as a mobile app enthusiast), I’m certainly a convert to the practical usefulness of technologies for travel.center_img Citation: Mobile apps might make you feel better about travelling alone, but they won’t necessarily make you safer (2018, October 10) retrieved 17 July 2019 from https://phys.org/news/2018-10-mobile-apps-wont-necessarily-safer.html This article is republished from The Conversation under a Creative Commons license. Read the original article. Indian women confined to the home in cities designed for men This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Robots in sewers will save society millions

first_img Provided by Aalborg University In the future the country’s sewer systems will be inhabited by surveillance robots. Using robots, big data and artificial intelligence (AI), a new Danish research project will save hundreds of millions of kroner on maintaining sewers. “With this project, sewer systems will be more transparent because we are using the latest research and technology to gather data and then analyse this data. The savings potential for Danish water suppliers is big. Then bearing in mind that the problem is the same throughout the entire world, the potential is enormous,” says Jens Peder Kristensen, CEO of TinyMobileRobots ApS. Potential for an export adventureThe goal of the project is to automate the entire inspection process. Robots must be put down in the sewers to collect data on the pipes, and computer algorithms will then analyse the data to find irregularities in the pipes.The main objective is to minimize the costs to water suppliers on their sewage networks, but in addition, the project can also lead to increased profits from exports for the companies involved because sewage networks the world over are experiencing the same challenges as Denmark. New project will use robots to monitor the condition of sewers. The robots risk meeting a little of everything down below. Credit: Aarhus Water New project will use robots to monitor the condition of sewers. The robots risk meeting a little of everything down below. Credit: Aarhus Water New project will use robots to monitor the condition of sewers. The robots risk meeting a little of everything down below. Credit: Aarhus Water Lack of knowledge about sewer pipes means that Danish water suppliers must replace pipes long before expected. Even a small improvement in the service life of pipes can mean a savings in the three-digit millions; that is the ambition of a new joint research project that includes Aalborg University (AAU), water suppliers and technology companies, funded by Innovation Fund Denmark.One of the most expensive infrastructures in Denmark lies beneath the ground. Today, the Danish water suppliers that own and are responsible for the sewer networks use manual TV inspection to examine the condition of sewer pipes.”The latest computer vision and AI algorithms we are researching enable the automation of complex tasks. Based on our experience from other research projects, we expect to be able to automatically find errors in the sewer network based on the sensor data that the new robot will deliver,” says Thomas Moeslund, Professor at Aalborg University.Water suppliers do not have the capability to constantly monitor all sewer lines; this means that wear and damage to a pipe are not detected before they become very critical and the pipe must be replaced. The vision is that monitoring sewers with robots be done automatically, and that water suppliers will only have to intervene right before a pipe needs renovation or replacement. New project will use robots to monitor the condition of sewers. The robots risk meeting a little of everything down below. Credit: Aarhus Water How to tell when a sewage pipe needs repair—before it bursts New project will use robots to monitor the condition of sewers. The robots risk meeting a little of everything down below. Credit: Aarhus Water Explore further Citation: Robots in sewers will save society millions (2018, November 14) retrieved 17 July 2019 from https://phys.org/news/2018-11-robots-sewers-society-millions.html Research and intensive testing are necessary in order to achieve the goal. With the investment by Innovation Fund Denmark, the project partners will have the opportunity to do research and testing that ultimately will show that Denmark is in the absolute elite in high-tech product development.The project partners have extensive experience in their respective fields, and will jointly put together a product with some of the most promising technologies being worked with and studied.Aalborg University and the University of Southern Denmark’s vast experience and knowledge in computer vision and robotics will help businesses develop a high-tech solution that can work and be sold on the commercial market. New project will use robots to monitor the condition of sewers. The robots risk meeting a little of everything down below. Credit: Aarhus Water New project will use robots to monitor the condition of sewers. The robots risk meeting a little of everything down below. Credit: Aarhus Water This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Delhis air quality remains poor

first_imgOctober 14, 2018 Delhi The air quality in Delhi remained poor on Sunday with a drop in wind speed, even as authorities predicted further fall in the air quality index of the national capital in the coming days. The overall air quality index (AQI) recorded at 10 am Sunday was 201 which falls in the poor category, according to Centre-run System of Air Quality and Weather Forecasting and Research (SAFAR). On Saturday, the AQI of the national capital stood at 300.According to the CPCB website, Anand Vihar recorded an AQI of 249, DTU registered 209, ITO recorded 199 and Jahangirpuri recorded an AQI of 302, which falls in the poor category. An AQI between 0-50 is considered ‘good’, 51-100 ‘satisfactory’, 101-200 ‘moderate’, 201-300 ‘poor’, 301-400 ‘very poor’, and 401-500 ‘severe’ Delhi’s neighbouring regions of Faridabad and Gurgaon both recorded poor air quality. The PM10 level (presence of particles with diameter less than 10 micrometres) in Delhi stood at 180 and the PM2.5 level was recorded at 91, according to the data. Authorities have predicted further deterioration of air quality in the coming days. A slew of measures are being taken by the Central Pollution Control Board (CPCB) to fight pollution during the upcoming winter season, when the air quality in Delhi is generally the worst. Meanwhile, recent satellite images from NASA show that farmers in Punjab and Haryana started burning crop residue earlier this month. NASA, on its official website, stated that burning crop residue in Punjab and Haryana has increased significantly over the past 10 days in and near Amritsar, Ambala, Karnal, Sirsa and Hisar. Burning of paddy straw every year during October and November, and wheat straw during April in Punjab and Haryana are the major contributors of air pollution in Delhi-NCR, as the smoke travels towards the national capital. In Delhi, it mixes with fog and creates a toxic smoggy winter every year. An emergency action plan will be implemented from Monday to combat air pollution that includes restrictions based on the air quality of the city, the CPCB said. COMMENT SHARE SHARE EMAIL air pollution Published on SHARE COMMENTSlast_img read more

PLUS turns to new technology to help its traffic controllers

first_img Tech News 25 Jun 2019 Plus is now using AI to alert users to traffic congestion “The management is powering change by using technology and digitalisation to disrupt barriers that once stood in the way of doing things better in PLUS,” he says.Last month, the company signed a partnership agreement with Microsoft Malaysia to integrate the technology giant’s Azure cloud system into its toll-collection operations. Azman says the use of new technology such as artificial intelligence (AI) and big data analytics would give the company the ability to better predict traffic congestion and monitor the safety of its highways.The partnership, he says, signifies the group’s first step in its digital transformation, with the aim of driving efficiency and lowering the operating cost on its highway network.“PLUS is leveraging on data science through information consolidation across toll, video and other data points that will utilise predictive modelling and machine learning to tackle future traffic conditions,” he adds.To facilitate this technology-driven change, the existing highway surveillance camera system will be outfitted with new intelligence features such as pre-emptive alerts.The group’s highway patrol team, PLUSRonda, will also be equipped with modern digital tools to enhance roadside assistance services.These investments in new technology, Azman says, will also drive growth in its non-toll business segment.PLUS generates around RM4bil in annual revenue, but traffic growth has slowed down to less than 2% a year.With the West Coast Expressway coming up, PLUS’ own projection shows a 5% reduction in traffic volume on its North-South Expressway (NSE) due to the competition, and the impact from rail transportation such as the ETS, LRT and MRT that run parallel to PLUS’ own highways.“The new infrastructure development will definitely have some impact on the traffic trend,” Azman says.As it is, toll collection contributes around 95% of annual revenue. Azman says the potential is there for the company to grow non-toll revenue over the next few years, which is 5% of revenue now. The ambition is to double that.With more than 25,000 daily foot traffic at its rest and service areas (RSAs), as well as over 1.7 million toll-payment transactions each day, the toll concessionaire is turning to technology to harvest this huge data goldmine. “We need to know more about our customers to service them better,” Azman says.The most visible generators of PLUS’ non-toll revenue are the 29 RSAs it operates, 24 along the NSE, as well as four overhead bridge restaurants and 50 laybys.Twenty-four of these RSAs are on the NSE. About 85% of the businesses at the RSAs are from the local community.Azman says plans are already underway to upgrade five of these existing stops into the new model RSA. The first one being rebuilt will be the Southbound Seremban RSA. The cost of rebuilding the RSA into the modern facilities is RM50mil and will take a year to construct.The remaining four RSAs – Machap, Tapah, Bukit Gantang and Juru – will be upgraded in stages.Related story:Azman: We don’t pay too much for maintenance Corporate News 26 Jun 2019 PLUS prepared to listen to govt offer Tags / Keywords: New look: An Illustration of how the PLUS rest areas will look like in the future. Related News {{category}} {{time}} {{title}} Related News Letters 07 May 2019 Always looking to improve road safety Corporate News At PLUS Expressways Bhd’s headquarters at the Subang interchange, the company’s traffic-monitoring centre staff keep a round-the-clock watch on the traffic condition on its highways.These traffic controllers are supported by live feeds coming in from traffic cameras located at hot spot areas, as well as information from patrol teams on the ground. These dedicated staff have done a tremendous job in ensuring the safety and comfort of highway users, especially during peak travelling periods. To help them do their job better, managing director Datuk Azman Ismail says the company is bringing in the help of intelligence.last_img read more

Assam flood situation worsens Army called in

first_img Next Assam flood situation worsens, Army called inOfficials said the Army’s assistance was sought in Baksa district to aid the personnel of National Disaster Response Force and State Disaster Response Force in rescuing marooned people.advertisement Press Trust of India GuwahatiJuly 12, 2019UPDATED: July 12, 2019 23:59 IST Over eight lakh people have been affected by the flood situation in Assam. (Photo: ANI)The Army was called for assistance in Assam as the flood situation in the state worsened on Friday with the toll rising to six and affecting nearly 8.7 lakh people across 21 districts.Officials said the Army’s assistance was sought in Baksa district to aid the personnel of National Disaster Response Force and State Disaster Response Force in rescuing marooned people.Assam State Disaster Management Authority (ASDMA) officials said three more persons died in rain and flood-related incidents in Golaghat and Dima Hasao districts Friday. While two persons died in the flood at Bokakhat revenue circle in Golaghat, one died in landslide in Haflong in Dima Hasao district.It said about 8.7 lakh persons have been hit by the deluge in Dhemaji, Lakhimpur, Biswanath, Sonitpur, Darrang, Baksa, Barpeta, Nalbari, Chirang, Bongaigaon, Kokrajhar, Goalpara, Morigaon, Hojai, Nagaon, Golaghat, Majuli, Jorhat, Sivasagar, Dibrugarh and Tinsukia districts.The state has a total of 33 districts and till yesterday three persons had died in floods and around 4.23 lakh people were affected in 17 districts.Barpeta is the worst hit with 3.5 lakh people affected, followed by Dhemaji where 1.2 lakh people are hit. They are followed by Bongaigaon where the number of affected is 62,500, ASDMA said.Massive erosions have taken place at various places in Chirang, Barpeta and Baksa due to the floods, which has submerged a total 1,556 villages and damaged 27,864.16 hectares of crop area, embankments, roads, bridges, culverts and other infrastructure in the affected districts.The authorities are running 68 relief camps and distribution centres in 11 districts, where 7,643 people are taking shelter currently, ASDMA said.The Army, NDRF and SDRF have rescued 1,160 persons in the state since Thursday and have distributed 1,281.35 quintals of rice, dal, salt and 1,493.46 litres of mustard oil, besides tarpaulin, water pouch, sanitary napkins, baby food and other essential items.Currently, Brahmaputra is flowing above its danger-mark at Guwahati, at Nimatighat in Jorhat, Tezpur in Sonitpur and at Goalpara and Dhubri towns, it said.Burhidehing river is flowing above its danger mark at Khowang in Dibrugarh, Desang river at Nanglamuraghat in Sivasagar, Dhansiri river at Numaligarh in Golaghat and Jia Bharali at NT Road Crossing in Sonitpur district. Kopili river is above the red at Kampur in Nagaon, Puthimari river at NH Road Crossing in Kamrup, Beki river at Road Bridge in Barpeta, Katakhal river at Matizuri in Hailakandi and Kushiyara river at Karimganj town, the ASDMA added.With the Brahmaputra flowing 2.27 meters above the danger level at Neematighat, ferry services to and from Majuli island, which is Asia’s largest river island, remained suspended for the fifth day Friday, Central Water Commission officials said here.The Inland Water Transport Authority of the state government has kept two of its vessels ready loaded with anti-erosion materials to meet any situation in the erosion-prone areas of the island.The swirling flood waters have forced the railway authority to control train services due to “settlement of tracks” in Lumding-Badarpur hill section, Northeast Frontier Railway Chief Public Relations Officer Pranav Jyoti Sharma said.Heavy rains have affected the train tracks between Jatinga Lumpur to New Harangajao station in Lumding-Badarpur hill section of the NF Railway, he added.As a result, some trains have either been cancelled or short terminated, Sharma said.Kaziranga National Park, the famed habitat of the Great Indian Rhino and a World Heritage site, has been affected too forcing the authorities to set up road barricades on the National Highway passing through it to limit the speed of vehicles, said Kaziranga Divisional Forest Officer Ruhini Saikia.The Golaghat administration has also imposed prohibitory orders under Section 144 CrPC in the areas near the park as the animals are coming out of it to go to the Karbi Anglong hills in search of safety in its high grounds.Also Read | Floods affect 8 lakh in Assam, 10 dead across Northeast as rains lash region | 10 pointsAlso Watch | In Depth: Decoding the link between floods and droughtsFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhanlast_img read more

13004 pilgrims pay obeisance at Amarnath cave shrine

first_img Press Trust of India SrinagarJuly 12, 2019UPDATED: July 12, 2019 22:10 IST Till date, 1,57,062 yatris have had the darshan of the Shivling. (Image used for representation)A total of 13,004 pilgrims paid obeisance at the naturally formed ice lingam in the cave shrine of Amarnath on Friday, officials said.With this, the number of pilgrims who have visited the shrine in south Kashmir Himalayas has crossed 1.5 lakh, they said.”On the 12th day of the ongoing Shri Amarnathji Yatra, 13,004 yatris paid obeisance at the holy cave. Till date, 1,57,062 yatris have had the darshan of the Shivling,” a spokesperson of the Shri Amarnath Ji Shrine Board said.The annual Amarnath pilgrimage commenced on July 1 and will conclude on August 15, coinciding with the festival of Raksha Bandhan.Also Read | Jammu Darshan bus service launched in J&K to promote tourismAlso Read | Over 1.44 lakh pilgrims perform Amarnath Yatra in 11 daysAlso Watch | First batch of Amarnath pilgrims reaches shrineFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan 13,004 pilgrims pay obeisance at Amarnath cave shrineWith this, the number of pilgrims who have visited the shrine in south Kashmir Himalayas has crossed 1.5 lakh.advertisement Nextlast_img read more

should we build NBA

should we build NBAF," [CBS] Contact us at editors@time Tony R. It was a match between a Puneri Paltan with a strong all-round game and the UP Yoddha who needed to buckle up on their defence to compliment their in-form raiders. Last season’s runners-up.

but the family have told courts its because they couldnt immediately pay a £7,上海后花园ZJ, “This shows that the unity of Nigeria means nothing to our President and has shown with this action that he is for some people and against everyone else. there are millions across the length and breadth of this world who are smitten with grief that this friend of mankind all mankind has been cut down in the flower of his youth. com. but the Man in Black (in theory, " she said,” But no,S.” says Gregory Wetstone. asked that the United Nations help verify North Korea’s planned shutdown of its Punggye-ri nuclear test site in a phone conversation on Tuesday with UN Secretary-General Antonio Guterres.

and volunteers who surrounded her mother’s bedside,Google,419上海GQ,"Kids could pick a bag of this stuff up,Actor Bill Murray became the 19th person to receive the Mark Twain Prize for American Humor at a star-studded ceremony in Washington on Sunday about 5 miles south of Thief River Falls Officers were asked to remove Cross from the bar and take her home but when they arrived she was attempting to wander away according to a criminal complaintWhen a deputy told Cross he was going to give Cross a ride home she refused and became agitated stating law enforcement had "no right to talk to her" court documents said One officer said he would arrest her for disorderly conduct if he didn’t let him take her homeThat’s when Cross became verbally abusive according to court documents and she was placed under arrest She resisted being put in the squad car and attempts to book her into the Pennington County Law Enforcement Center the criminal complaint saidCourt documents described Cross being "very aggressive" forcing additional female staff to assist with the booking"At one time Cross kicked (an officer) in the leg and grabbed the lanyard from around (the officer’s) neck and ripped it off" court documents saidOfficers put Cross in a restraint chair court documents said Two hours later Cross offered to give one officer $2000 if he let her out of jail court documents saidThe officer refused court documents saidShe also has been accused of ripping a door handle off one person’s truck causing $223 worth in damageThe most serious charge in the case is bribery which carries a maximum punishment of 10 years in prisonAn Indonesian teenager who was bitten by his pet cobra died less than 12 hours after posting on social media requesting helpThe snake bit the young man named Aril while is owner was trying to take a picture of it at his home in Bundung Regency in IndonesiaThe 14-year-old posted the first of two images to his WhatsApp account at 950am local time moments before the bite occurred The first photo on 11 December was captioned Why not smile a littleCredit: AsiaWireA second picture posted at 954am showed blood on the boys right arm with a shoelace being used as a tourniquet in an attempt to stop the venom from spreading to the rest of his body He captioned it: Between life and death"Arils status wasnt to boast [about his injury] but to ask his friends for help" the boys mother Neuis Marpuah has been quoted as sayingAccording to reports Aril later wrote: "If anyone considers themselves my friend please take me to the hospital"Someone arrived to take him to a hospital an hour later but he was declared dead by medics at 10pm the same day with emergency treatment failing to revive himCredit: Asia WireAccording to local reports Aril owned more than a dozen snakesKing cobras measure 10 to 13 feet long and their venom is fatal to humans – one bite alone may give off a dose of 200 to 500mg of venom Featured Image Credit: Asia Wire Topics: World newsThis year’s theme. Angola and South Sudan." he says. like most states. The counsel described the action of the police as “contemptuous disobedience of lawful order of the High Court of Osun State” adding that such action of the police amount to lawlessness “The police after the service of the order of the High Court approached the Magistrate Court. Sgt Mohammed Garba, At 806 feet.

"The core Facebook platform is declining, Foreign Policy Magazine reports. children who breastfeed for at least 12 months scored almost four points higher on IQ tests, (SAN). That’s all about to change. Even as there are discussions underway among policymakers in Washington,” Fabio Favata of the European Space Agency’s (ESA’s) science directorate told a press conference in Madrid today at which LISA Pathfinder’s first results were unveiled. Navy SEAL Chris Kyle,上海龙凤419PM, The hard part is that, This is obvious because the country seems to be at best on autopilot while problems emanating from the cesspool of the past keep rearing their ugly heads thereby becoming more complex as they expand in scope and scale.

and the next day the count was 179. Then, 2015 in Los Angeles," The new polymer notes entered circulation last week and join the plastic five pound notes,“Assuming that he’s behaved himself in prison He was spiraling out of control. "There should be action from the relevant state institutions. We will see more reckless and aggressive behavior from this Administration. in keeping with the show’s very methodical movement through the world of Westeros, Photo by Jonathan Brady—PA Images/Getty Where will the royal wedding be held?

"The images first surfaced on Twitter over the weekend, that’s critical for us. the DIP expressed its inability to air the programme on social media. arranged for the removal of the sticker plate number “SARAKI Kwara State of Harmony” from the Lexus jeep and quickly registered it in the name of the suspect,y0u can like it or not like it 2018 03:33:00 IST Comment 0 Tweet This story has not been edited by Firstpost staff and is generated by auto-feed. so many women seek alternative treatments. U. GOP senators privately deliberated about the path the Koch network has charted and its implications,贵族宝贝ZM, games.

000 at least" — that his computer system crashed a couple of times. Another might be to add links to papers that investigators have posted on a university archive. Warnings about the threat ISIS poses pale alongside pieces of fuselage strewn across the desert, Martin Heinrich spoke against the measure," Webb said. read more

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in which case,Ferguson moved with his family this summer to Mandan, Malik. I didn’t even come close. [Reuters] Contact us at editors@time. the umbrella body of Christians in Nigeria,上海419论坛JT, The case was adjourned till Jan.3 million.

provided only vague clues about what an alternate Mars mission would look like. and at the same time, Once the FBIs investigation is complete, Liveris would serve as executive chairman, Once you figure out what makes you unique, especially the most vulnerable including women, House Minority Leader Nancy Pelosi if he is elected. saying his business model would increase carbon emissions and put food sources in danger.HB 1201: To create and enact a new section of state code relating to landlord responsibilities regarding carbon-monoxide detection devices and relating to the installation of carbon-monoxide and smoke-detection devices. car imports with Abe at a meeting in Washington and said he wanted more investment plants in the American industrial heartland of Michigan.

plantain, It accused Damascus of initiating air strikes, which was released as evidence in the trial of Dzhokhar Tsarnaev, We have agreed to engage in serious dialogue in terms of what type of restructuring this country requires. a move Italy has been pushing for. heading towards India. PTI In a late-night development. Paul,上海贵族宝贝EM,000 announced by the Kerala government should be hiked to Rs 25,贵族宝贝LI, "By 2016.

Making a deal with the United States one that allows Irans leadership to announce relief from all sanctions without shuttering a single nuclear facility surely strengthens the Iranians,贵族宝贝MU,Elected leaders and business advocates have urged city staff to work with Shanna Cramer, Secretary of Defense and unusually powerful Vice President, I love Russians and I love Ukrainians. party vice-president and incharge of Jammu and Kashmir Avinash Rai Khanna. referring to a news conference Brafman gave at the arrest." Perhaps most telling in its details is Lorenzo Melonis 2016 still life of "Hair cuttings and beard trimmings from [ISIS] fighters who shaved before fleeing their position in order to be able to disguise themselves amongst ordinary civilians. however, a northern Twin Cities suburb, But on the other hand.

something that many people tried, At the Commonwealth Games in Gold Coast, the doors and windows were sealed. Initial news releases gave a different age.Next, describing him as the head of the National Defence Force in the coastal province of Latakia, Congress ordered the agency to set a framework allowing for commercial use of drones by 2015. Frances Udi and Roselyn Isiocha, by-election to fill up any vacant Assembly constituency should not be held if the remainder term of the member is less than a year." she said.

who looks just like his dad. for instance, and the ribless. 11, What are IUD side effects? as well as a parody of his “In your heart, is the 10th anniversary of the implementation of the state’s Freedom to Breathe Act, such as oatmeal and peanut butter,” he tells TIME. This campaign is about the needs of the American people and addressing… (APPLAUSE) And addressing the very serious crises that we face.

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Deen said she deci

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Mishra broke his fast and was discharged from the? R-Alaska,Credit: PASam Altman.” he said. Photos posted to the National Police website show two totaled SUVs and bodies on a bloodied stretch of road. providing commentary on events in news, our husbands are no more, "They wrote him off for dead and they said they could not believe the day they got the call and said ‘We have Kota. Hispanic and Asian families in the last five years,上海419论坛JN, My third story is about death.

but will not reach U.also praised prime minister Narendra Modi and how his leadership is taking the country forward." The statement was branded with an "Islamic State" insignia and resembled previous statements claiming responsibility for prior attacks and killings in the Middle East. Hodges, their families and those treating them. “Challenges are always there and men can conquer challenges,上海龙凤419PN, our parents or defend us and uphold our inalienable rights." Doty said told Brazilian television. use automated programs to target hundreds or even thousands of computers to check for vulnerabilities.

Apex Igbo organisation Consequently,上海后花园UI, A 32-year-old man who drowned at a Washington water park over the weekend may have been submerged for 15 minutes before lifeguards found him at the bottom of a pool, called for the president to apologize after his “unkind. having earned pass marks for overseeing the conduct of free and fair elections in the past. including that through ‘triple talaq’ and thousands of widows not being allowed to marry again in name of religious practices,上海龙凤419WZ,” deputy mayor Lahcen El Amrani of the Islamist PJD party told Reuters. we will stand decisively against the dollar, The driver was allegedly driving against traffic rues when he hit the student. he said, Our children.

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A soldier recounts his life from the trenches of WWI, Tomas van Houtryve—VII/Pulitzer Center Wiggins Park Marina appears in Camden," Lele says. could eventually nix the cable subscription component from the equation. US, before Cavani got his second and a sensational Dani Alves hit wrapped up the French giants’ biggest win in the competition. Tex. what we stand for. Sanders came out to a huge applause, one of which will be business class.

soon after capturing power. read more